Main description:

A multidisciplinary survey of our current understanding of the biological and clinical aspects of vascular disease. The authors describe its basic mechanisms, its clinical characteristics, its pharmacological management, and the use of neuroimaging methods to investigate it. The complex relationship between VaD and AD is also fully explored with chapters on how these processes interact and how one disease may lower the threshold for clinical expression of the other.

Contents:

Part I. Introduction

The Aging Population and the Relevance of Vascular Dementia
Kelly L. Lange and Robert H. Paul

Clinical Forms of Vascular Dementia
Gustavo C. Roman

The Neuropathological Substrates of Vascular-Ischemic Dementia
Kurt A. Jellinger

Diagnosis of Vascular Dementia: Conceptual Challenges
Jose G. Merino and Vladimir Hachinski

Part II. Basic Mechanisms of Vascular Dementia

Cerebral Hemodynamics in the Elderly
Jorge M. Serrador, William P. Milberg, and Lewis A. Lipsitz

The CADASIL Syndrome and Other Genetic Causes of Stroke and Vascular Dementia
Stephen Salloway and Sophie Desbiens

Estrogen, the Cerebrovascular System, and Dementia
Sharon X. C. Yang and George A. Kuchel

Effects of Hypertension in Young Adult and Middle-Aged Rhesus Monkeys
Mark B. Moss and Elizabeth M. Jonak

Part III. The Impact of Vascular Dementia on Cognitive, Psychiatric, and Daily Living

The Cognitive Profile of Vascular Dementia
Angela L. Jefferson, Adam M. Brickman, Mark S. Aloia, and Robert H. Paul

Progression of Cognitive Impairments Associated With Cerebrovascular Disease
Sally Stephens, Raj Kalaria, Rose Anne Kenny, and Clive Ballard

Neuropsychiatric Correlates of Vascular Injury: Vascular Dementia and Related Neurobehavioral Syndromes
Anand Kumar, Helen Lavretsky, and Ebrahim Haroon

Functional Impairment in Vascular Dementia
Patricia A. Boyle and Deborah Cahn-Weiner

Part IV. Neuroimaging of Vascular Dementia

Functional Brain Imaging of Cerebrovascular Disease
Ronald Cohen, Lawrence Sweet, David F. Tate, and Marc Fisher

Contributions of Subcortical Lacunar Infarcts to Cognitive Impairment in Older Persons
Dan Mungas

White Matter Hyperintensities and Cognition
David J. Moser, Jason E. Kanz, and Kelly D.Garrett

Poststroke Dementia: The Role of Strategic Infarcts
Anelyssa D'Abreu and Brian R. Ott

Part V. Interactions Between Vascular Dementia and Alzheimer's Disease

Understanding Incidence and Prevalence Rates in Mixed Dementia
John Gunstad and Jeffrey Browndyke

Vascular Basement Membrane Abnormalities and Alzheimer's Disease
Edward G. Stopa, Brian D. Zipser, and John E. Donahue

Amyloid Beta and the Cerebral Vasculature
Paula Grammas

Cerebrovascular Disease and the Expression of Alzheimer's Disease
Margaret M. Esiri and Zsuzsanna Nagy

The Neuropsychological Differentiation Between Alzheimer's Disease and Subcortical Vascular Dementia
David J. Libon, Stephen Scheinthal, Dana L. Penney, and Rod Swenson

Part VI. Clinical Management of Vascular Dementia

Pharmacological Treatment of Vascular Dementia
Timo Erkinjuntti, Gustavo Roman, Serge Gauthier, and Kenneth Rockwood

Understanding and Managing Caregiver Burden in Cerebrovascular Disease
Geoffrey Tremont, Jennifer Duncan Davis, and Mary Beth Spitznagel

Quality of Life in Patients With Vascular Dementia
Rebecca E. Ready and Brian R. Ott

Approaches to Neuroprotection and Recovery Enhancement After Acute Stroke
Marc Fisher and Magdy Selim

Index