Main description:

Advances in the study and understanding of myasthenia gravis have led to the need for the publication of this important new edition. The goal of Myasthenia Gravis and Related Disorders, Second Edition is identical to the first -- to provide the clinician and the scientist with a common resource for understanding this complex disorder. This new edition begins with discussions of neuromuscular junction structure and function and follows with updated chapters covering a wide range of topics, such as the acetylcholine receptor, clinical presentation, diagnostic evaluation, and treatment. Importantly, new supplemental chapters have been added; these discuss rigorous clinical assessments of patients for research trials and the epidemiology and genetics of myasthenia gravis. The discussion of the most challenging aspects of myasthenia gravis, its impact on patients' psychological make-up, has been expanded as well. Myasthenia Gravis and Related Disorders, Second Edition retains the "personal approach" of the authors regarding treatment and is a valuable resource for meeting the many and varied needs of patients with myasthenia gravis.

Contents:

Preface
Henry J. Kaminski, MD

Chapter 1 Neuromuscular Junction Physiology and Pathophysiology
Eroboghene E. Ubogu, MD and Robert L. Ruff, MD, PhD

Chapter 2 Acetylcholine Receptor Structure
Jon Lindstrom PhD

Chapter 3 Immunopathogenesis of Myasthenia Gravis
Bianca M. Conti-Fine, MD, Brenda Diethelm-Okita, Norma Ostlie, MS, Wei Wang, MD, PhD and Monica Milani

Chapter 4 Epidemiology and Genetics of Myasthenia Gravis
Jeremiah W. Lanford, MD and Lawrence H. Phillips, II, MD

Chapter 5
Clinical Presentations of Generalized Myasthenia Gravis
Jan B.M. Kuks, MD

Chapter 6 Ocular Myasthenia
Robert B. Daroff, MD and Michael Benatar, MBChB, DPhil

Chapter 7 Thymoma-Associated Myasthenia Gravis
Philipp Stroebel, MD, Wen-Yu Chuang, MD and Alexander Marx, MD

Chapter 8 Electrodiagnosis of Neuromuscular Transmission and Related Disorders
Bashar Katiriji, MD, FACP

Chapter 9 Autoantibody Testing in the Diagnosis and Management of Autoimmune Disorders of Neuromuscular Transmission and Related Diseases
Mark A. Agius, MD, David P. Richman, MD and Angela Vincent, MB, FRCPath

Chapter 10 Treatment of Myasthenia Gravis
Henry J. Kaminski, MD

Chapter 11 Neurocritical Care of Myasthenic Crisis
J. Americo Fernandes Filho, MD and Jose I Suarez, MD

Chapter 12 Thymectomy for Nonthymomatous Myasthenia Gravis
Alfred Jaretzki, MD and Joshua R. Sonett, MD

Chapter 13 Lambert-Eaton Syndrome
Charles M. Harper, Jr., MD and Vanda A. Lennon, MD, PhD

Chapter 14 Neuromyotonia and other Hyperexcitability Syndromes
Angela Vincent, MB, FRCPath and Ian Hart, PhD, FRCP

Chapter 15 Congenital Myasthenic Syndromes
David Beeson, PhD

Chapter 16 Toxic NeuromuscularTransmission Disorders
James Howard, MD

Chapter 17 The Impact of Myasthenia Gravis on Mood, Cognitive Function, and Quality of Life
Robert H. Paul, PhD, Larry L. Mullins, and James M. Gilchrist

Chapter 18 Myasthenia gravis: Classification and Outcome Measurements
Gil I. Wolfe and Richard J. Barohn