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Main description:
"Rule IV. There is need of a method for finding out the truth. Rule V. Method consists entirely in the order and disposition of the objects toward which our mental vision must be directed if we would find out any truth. We shall comply with it exactly if we reduce involved and obscure propositions step be step to those that are s- pler, and then starting with the intuitive apprehension of all those that are absolutely simple, attempt to ascend to the knowledge of all others by precisely similar steps. " -Rene Descartes, Rules for the Direction of Mind "...Perhaps he would sooner satisfy himself by resolving light into colours as far as may be done by Art, and then by examining the properties of those colours apart, and afterwards by trying the effects of reconjoyning two or more or all of those, and lastly by separating them again to examine what changes that reconjunction had wrought in them. This will prove a tedious and difficult task to do it as it ought to be done but I could not be satisfied till I had gone through it. " -From Newton's letter, quoted in The Life of Isaac Newton by Richard Westfall. Cambridge University Press, 1993.
Contents:
Part I. Optimizing the Usage of Models of Renal Disease
Standards of Animal Care in Biological Experiments
Ellen M. Levee
Models of Polycystic Kidney Disease
Poornima Upadhya
Rat Models of the Metabolic Syndrome
Stevan P. Tofovic and Edwin K. Jackson
Models of Glomerulonephritis
Raghu V. Durvasula and Stuart J. Shankland
Part II. Choices of Imaging Techniques in Studies of Renal Disease
Functional Studies of the Kidney with Magnetic Resonance Imaging
Hani B. Marcos, Yantian Zhang, and Peter L. Choyke
Use of Radionuclides to Study Renal Function
Yiyan Liu and M. Donald Blaufox
Intravital Videomicroscopy
Tokunori Yamamoto and Fumihiko Kajiya
Confocal and Two-Photon Microscopy
Janos Peti-Peterdi and P. Darwin Bell
Atomic Force Microscopy in Renal Physiology
Robert M. Henderson
Freeze-Fracture Analysis of Renal-Epithelial Tight Junctions
Hiroyuki Sasaki
Part III. Studies of Renal Development
Organ Culture of Intact Metanephric Kidneys
Simon J. M. Welham and Adrian S. Woolf
The Ureteric Bud: Tissue-Culture Approaches to Branching Morphogenesis and Inductive Signaling
Alan O. Perantoni
Studies of Cell Lineage in the Developing Kidney
Maria Luisa S. Sequeira Lopez and R. Ariel Gomez
Transient Transfection Assays for Analysis of Signal Transduction in Renal Cells
Robin L. Maser, Brenda S. Magenheimer, Christopher A. Zien, and James P. Calvet
Part IV. Approaches to Study Molecular Mechanisms of Disease
The Study of Gene Polymorphisms: How Complex Is Complex Genetic Disease?
Sylvia Bahring, Atakan Aydin, and Friedrich C. Luft
Laser-Capture Microdissection
Laura Barisoni and Robert A. Star
Serial Analysis of Gene Expression
M. Ashraf El-Meanawy, Shrinath Barathan, Patrick S.Hayden, Sudha K. Iyengar, Jeffrey R. Schelling, and John R. Sedor
RNA Labeling and Hybridization of DNA Microarrays
Erwin P. Boettinger, Akiva Novetsky, and Jiri Zavadil
Gene-Expression Analysis of Microdissected Renal Biopsies
Clemens D. Cohen and Matthias Kretzler
The Use of SELDI ProteinChip (R) Array Technology in Renal Disease Research
Eric Fung, Deb Diamond, Anja Hviid Simonsesn, and Scot R. Weinberger
Part V. Technical Means to Assess Functional Correlates of Disease
Clearance Studies in Genetically Altered Mice
William T. Noonan and John N. Lorenz
Long-Term Blood-Pressure Monitoring in Unrestrained Animals
Karen A. Griffin, Isam Abu-Amarah, and Anil K. Bidani
In Vitro Studies on Renin Release
Boye L. Jensen, Ulla G. Friis, and Ole Skott
Mitochondrial Function
Joel M. Weinberg and Pothana Saikumar
Detection of Cysteine S-Nitrosylation and Tyrosine 3-Nitration in Kidney Proteins
Mark Crabtree, Gang Hao, and Steven S. Gross
Products of Arachidonic Acid Metabolism
Mairead A. Carroll, John C. McGiff, and Nicholas R. Ferreri
Methods for Measurements of Heme Oxygenase (HO) Isoforms-Mediated Synthesis of Carbon Monoxide and HO-1 and HO-2 Proteins
Nader G. Abraham, Houli Jiang, Michael Balazy, and Alvin I. Goodman
The Juxtamedullary Nephron Preparation
Daniel Casellas and Leon C. Moore
Tubuloglomerular Feedback
Volker Vallon and Jurgen Schnermann
Microdissected Perfused Vessels
Thomas L. Pallone
Renal Microperfusion Techniques
Charles S. Wingo, I. David Weiner, and Shen-Ling Xia
How to Design a Clinical Trial
Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey
Conclusion
Michael S. Goligorsky
Index
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 520
Weight: 836g
Availability: Available
Subcategories: Urology
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