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Main description:
The development of cancer is a slow process and it very often takes a number of years before a tumor becomes clinically evident. No current te- nique is sensitive and specific enough to detect tumors at their earliest stage, i. e. , when the tumor is smaller than one billion cells. Consequently, the d- ease is usually diagnosed in an advanced state, very often when it is already beyond the reach of therapeutic strategies. This is the main stumbling block to the secondary prevention that would reduce cancer mortality. There is hope, however, because in the last decade we have witnessed an explosion of reports dealing with tumor markers. In many instances, simple, noninvasive diagnostic tests are becoming available to detect the early signs ofneoplasia. Interest in early detection of neoplasia is growing among those basic scientists, cli- cians, and health professionals who realize that progress in reducing cancer mortality is dependent to a great degree on its early detection and prevention. Some disappointment usually accompanies these discoveries, because what at first glance proves to be promising, is in many instances, applicable only to a limited number of cases. What is the cause of these failures? The answer may be that cancer is a multitude of neoplastic diseases in which endogenous and exogenous etiologic factors contribute either sim- taneously or over a lifetime to the development of disease.
Contents:
Part I. Multiple Markers: Principles and Guidelines
Integrating Multiple Clinical Tests to Increase Predictive Power
Harry B. Burke
Statistical Considerations in the Analysis of Tumor Markers
Dennis A. Johnston
Selection and Development of Biomarkers for Bladder Cancer
George P. Hemstreet III, Robert E. Hurst, and Rebecca B. Bonner
Clinical Application of Tissue and Serum Markers in Breast Cancer
Gordon F. Schwartz and Roland Schwarting
Part II. Immunodiagnosis of Cancer: Serum and Tissue Markers
Serum and Tissue Biomarkers in the Prognosis and Treatment of Breast Cancer
Tina J. Heiken and Rajeshwari R. Mehta
The Oncofetal Protein p65 in Breast Cancer Detection
Margaret Hanausek, Zbigniew Walaszek, Ute Sherman, and Jerzy T. Klijanienko
Determination of Tumor Ferritin Concentration in Breast Cancer
Jonathan F. Head and Robert L. Elliott
Immunodiagnosis of Childhood Malignancies
David M. Parham and Hallie Holt
Immunohistochemical Evaluation of Biomarkers in Prostatic and Colorectal Neoplasia: Principles and Guidelines
William E. Grizzle, Russell B. Myers, Upender Manne, and Sudhir Srivastava
Factors Affecting Immunohistochemical Evaluation of Biomarker Expression in Neoplasia
William E. Grizzle, Russell B. Myers, Upender Manne, Cecil Rob Stockard, Lualhati E. Harkins, and Sidhir Srivastava
Instrumentation, Accuracy, and Quality Control Issues in Development of Quantitative Fluorescence-Image Analysis (QFIA)
Rebecca B. Bonner, Rubert E. Hurst, Jian Yu Rao, and George P. Hemstreet
Part III. Cytogenetic Markers
Cytogenetics as a Diagnostic Aid for Childhood Hematologic Disorders: Conventional Cytogenetic Techniques, Fluorescence In Situ Hybridization, and Comparative Genomic Hybridization
Susanna C. Raimondi, Susan Mathew, and Ching-Hon Pui
Preparation of Metaphase Chromosomes for Cytogenetic Analysis
Kevin A. Hahn and Penny K. Riggs
Chromosome Staining and Banding Techniques
Kevin A. Hahn and Penny K. Riggs
Fluorescence In Situ Hybridization to Chromosomes
Penny K. Riggs and Kevin A. Hahn
Detection of Rearrangements in the bcl-2 Gene Using the Polymerase Chain Reaction
Ruth W. Craig, Dorothy R. Belloni, Ernest S. Kawasaki, and Norman B. Levy
Part IV. Molecular Markers
Applications of Tissue Microdissection in Molecular Pathology: Principles and Guidelines
Michael R. Emmert-Buck, Irina A. Lubensky, Rodrigo F. Chuaqui, Larisa V. Debelenko, Cathy D. Vocke, Maria J. Merino, Paul H. Duray, W. Marston Linehan, Lance A. Liotta, and Zhengping Zhuang
EWS Gene Fusions as Diagnostic Markers in Sarcomas: Principles and Guidelines
Marc Ladanyi
p53 Detection in Breast Cancer
Penelope L. Davis and J. Dirk Iglehart
Use of the Polymerase Chain Reaction Technique to Detect the t(14;18) Translocation in Lymphoid Tissue
Maryalice Stetler-Stevenson and Megan S. Lim
Detection of ras Gene Mutations Using Oligonucleotide Ligation Technology
Faye A. Eggerding
Detection of Prostate-Cancer Cells in Blood and Bone Marrow by RT-PCR
Robert L. Vessella and Eva Corey
Quantitative, Competitive RT-PCR Analysis of Biomarkers in the Study of Neoplasia
Richard D. Hockett Jr., Miriam D. Rogers, and Sudhir Srivastava
Differential Display to Define Molecular Markers and Genes That Mediate Malignancy
Edward J. Pavlik, Katherine Nelson, Suseela Srinivasan, Thomas L. Johnson, and Paul D. DePriest
Part V. Miscellaneous Markers and Early Detection of Cancer
Transforming Growth Factor Beta: A Plasma Tumor Marker
Feng-Ming Kong, Mitchell S. Anscher, and Randy L. Jirtle
Anti-HMdU Autoantibodies in Human Sera as a Biomarker of Canc
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 516
Weight: 751g
Availability: Available
Subcategories: Pathology
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