Main description:

This book of the series on "Advances in Biochemistry in Health and Disease" includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.

Contents:

TABLE OF CONTENTS
A. INTRODUCTION
1. Juan M. SaavedraDepartment of Pharmacology and Physiology, Georgetown University Medical CenterWashington, USA. Email: juan.saavedra@georgetown.eduTitle: Therapeutic efficacy of angiotensin II blockade beyond heart diseases
2. Robson Augusto Souza SantosDepartment of Physiology and Biophysics, Federal University of Minas Gerais Belo Horizonte, BrazilEmail: robsonsant@gmail.comTitle: Prospective mechanisms linking renin-angiotensin system with a wide-ranging diseases
3. P.S. Tappia, S.K. Bhullar and N.S. DhallaAsper Clinical Research Institute, St. Boniface HospitalWinnipeg, Canada; Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre Winnipeg, Manitoba, CanadaEmail: nsdhalla@sbrc.caTitle: Role of renin-angiotensin system signaling transduction in varied diseases
B. CANCER
4. Talia Wegman-OstroskyDivision of Research, National Cancer Institute MexicoMexico Email: taliaw@gmail.com Title: Key role of systemic and local renin-angiotensin system in carcinogenesis
5. Rakshanda Layeequr RahmanDepartment of Surgery, School of Medicine, Texas Tech University, LubbockTexas, USAEmail: rakhshanda.rahman@ttuhsc.eduTitle: Prospective mechanisms linking renin-angiotensin system with cancer
6. Eleanor I AgerDepartment of Surgery, Austin Health, University of Melbourne Victoria, AustraliaEmail: eager@unimelb.edu.auTitle: Involvement of renin-angiotensin system in cellular processes of cancer 7. Anna M. CzarneckaDepartment of Oncology, Military Institute of MedicineWarsaw, PolandEmail: anna.czarnecka@gmail.comTitle: Molecular characterization of renin angiotensin system in cancer
8. Kirsty G. PringleSchool of Biomedical Sciences and Pharmacy University of NewcastleNewcastle, Australia Email: kirsty.pringle@newcastle.edu.auTitle: Hypoxia and tissue renin angiotensin system in tumor development
9. Clara Nahmias Gustave Roussy Institution of Cancer and Molecular Medicine Villejuif, France E-mail: clara.nahmias@inserm.frTitle: Functions of angiotensin receptors in cancer
10. Rakesh K. JainDepartment of Oncology, Harvard Medical School and Massachusetts General HospitalBoston, USAEmail: jain@steele.mgh.harvard.eduTitle: Targeting the renin-angiotensin system to improve cancer treatment
11. Ashwini L. ChandSchool of Cancer Medicine, La Trobe University, HeidelbergVictoria, AustraliaEmail: Ashwini.chand@onjcri.org.auTitle: Beneficial effects of the renin-angiotensin system inhibitors as cancer treatments
12. Swee T. TanGillies McIndoe Research InstituteWellington, New ZealandE-mail: swee.tan@gmri.org.nzTitle: Role of Renin-Angiotensin System in therapeutic targeting of cancer stem cells
C. LIVER DISEASES
13. Peter W. AngusDepartment of Medicine, The University of Melbourne, Austin and Northern Health, Melbourne Victoria, AustraliaEmail: peter.angus@austin.org.auTitle: Liver disease and the renin-angiotensin system: recent discoveries

14. Giovanni SansoeGastroenterology Unit, Humanitas Gradenigo Hospital, CorsoTorino, Italy.Email: giovannisan@iol.itTitle: Signaling pathways of the renin-angiotensin system in chronic liver disease
15. Florence WongDepartment of Medicine, Toronto General Hospital, University of Toronto,Toronto, CanadaEmail: florence.wong@utoronto.caTitle: Role of renin-angiotensin system in pathogenesis of liver cirrhosis
16. Ramon BatallerInstitute of Metabolomics and Digestives Hospital ClinicBarcelona, SpainEmail: bataller@clinic.ub.esTitle: Renin-angiotensin system and liver fibrogenesis
17. Leon FerderSchool of Medicine, University of Buenos Aires Buenos Aires, ArgentinaEmail: leferder@psm.eduTitle: Renin-angiotensin system components gene expression and liver disease
18. Kosuke KajDepartment of Internal Medicine, Nara Medical University Kashihara, Japan.Email: kajik@naramed-u.ac.jpTitle: Renin-angiotensin system and oxidative Stress: Involvement in chronic liver diseases
19. Pere Gines Liver Unit, Hospital Clinic of Barcelona, University of Barcelona Barcelona, SpainEmail: pgines@clinic.catTitle: Targeting the renin-angiotensin system in liver diseases
20. Josephine A. Grace Department of Medicine, University of Melbourne, Austin Hospital, HeidelbergMelbourne, AustraliaEmail j.grace4@pgrad.unimelb.edu.auTitle: Renin-angiotensin system in liver disease: Clinical implications
D. LUNG DISEASES
21. Keiji KubaInstitute of Molecular Biotechnology of the Austrian Academy of Sciences Vienna, AustriaEmail: Keiji.kuba@imba.oeaw.ac.atTitle: Role of renin -angiotensin system in lung diseases
22. Hongpeng JiaDepartment of Surgery, Johns Hopkins UniversityBaltimore, USAEmail: hjia4@jhmi.eduTitle: Tissue renin-angiotensin system and inflammatory response in lung disease
23. Fedor SimkoInstitute of Experimental Endocrinology Biomedical Research Center, Slovak Academy of SciencesBratislava, SlovakEmail: fedor.simko@fmed.uniba.skTitle: Involvement of renin-angiotensin system in the pathogenesis of acute respiratory distress syndrome
24. Daniela Fanni Department of Radiology, University Teaching HospitalCagliari, Italy Email: daniela.fanni@unica.it Title: Renin angiotensin system components and molecular pathways triggered by lung disease
25. Riccardo SarzaniDepartment of Clinical and Molecular Sciences, Marche Polytechnic UniversityAncona, ItalyEmail: r.sarzani@univpm.itTitle: Renin-angiotensin system and lung injury
26. Maria Jose Campagnole-SantosDepartment of Physiology and Biophysics, Federal University of Minas GeraisBelo Horizonte, BrazilEmail: mjcs@icb.ufmg.brTitle: Renin-angiotensin system components, inflammation and asthma
27. S. AndreasImmenhausen Lung ClinicImmenhausen, GermanyE-mail: sandreas@med.unigoettingen.deTitle: Angiotensin II blockers in obstructive pulmonary disease
E. INFECTIOUS DISEASES
28. Jawahar L. MehtaDepartment of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock Arkansas, USAEmail: mehtajl@uams.eduTitle: Renin angiotensin system: Pathophysiology and implications in infectious diseases
29. Sophie LiabeufDepartment of Clinical Pharmacology, Amiens University HospitalAmiens, FranceEmail: liabeuf.sophie@chu-amiens.frTitle: Renin-angiotensin system and COVID-19 infection
30. Suman SrinivasaMassachusetts General HospitalBoston, USAEmail: ssrinivasa@mgh.harvard.eduTitle: Renin-angiotensin-aldosterone system in human immunodeficiency virus
31. Muscha Steckelings Center for Cardiovascular Research, Institute of Pharmacology, Charite UniversityBerlin, GermanyE-mail ulrike.steckelings@charite.deTitle: Role of renin-angiotensin system in an infectious hazard: Chronic inflammation
32. Fedor SimkoBiomedical Research Center, Slovak Academy of SciencesBratislava, SlovakEmail: fedor.simko@fmed.uniba.skTitle: ACE/Ang II/AT1R cascade in acute respiratory distress syndrome and pneumonia
33. Jesper HallasDepartment of Clinical Pharmacology and Pharmacy, University of Southern Denmark Odense, DenmarkE-mail: jhallas@health.sdu.dkTitle: Renin-angiotensin system blockers and influenza
34. Ramesh K. GoyalDelhi Pharmaceutical Sciences and Research University New Delhi, IndiaEmail: goyalrk@gmail.comTitle: Renin-angiotensin modulation: Prevention and treatment of infectious diseases
35. F. Ferrara Department of Pharmaceutical, USI Umbria, Medical & Health Government Organization Perugia, Italy. Email: francesco.ferrara@uslumbria1.itTitle: Role of ACE/ACE2 balance in treatment of infectious diseases