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MORE ABOUT THIS BOOK
Main description:
The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.
Contents:
Chapter 1. Total Synthesis of Pachastrissamine (Jaspine B) .- Chapter 2. Total Synthesis of Lysergic Acid, Lysergol, and Isolysergol .- Chapter 3. Conclusions.
PRODUCT DETAILS
Publisher: Springer (Springer Verlag, Japan)
Publication date: November, 2011
Pages: 124
Weight: 360g
Availability: Available
Subcategories: Biochemistry
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