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MORE ABOUT THIS BOOK
Main description:
Entry Inhibitors in HIV Therapy details the current status of this relatively new and very dynamic class of inhibitors. A unique overview of obstacles and accomplishments is presented. The impact of viral sequence diversity on this class of inhibitors is discussed, and a connection between basic research and clinical studies is shown. The book presents a unique collection of contributors from basic research, pharmaceutical research, and the clinic.
Contents:
Introduction to entry inhibitors in the management of HIV infection.- The challenge of HIV sequence diversity in the envelope glycoproteins.- Attachment of human immunodeficiency virus to cells and its inhibition.- Inhibitors that target gp120-CD4 interactions.- Inhibitors that target gp120 interactions with coreceptor.- Inhibitors that target fusion.- Entry inhibitors as microbicides.- Entry inhibition of HIV-1 subtype C isolates.- The utility of coreceptor typing in the clinic.- Future clinical prospects for entry inhibitors.- Enfuvirtide: from basic science to FDA approval.- Targets for drug development - past and present.
PRODUCT DETAILS
Publisher: Springer (Birkhauser Verlag AG)
Publication date: June, 2007
Pages: 209
Weight: 569g
Availability: Available
Subcategories: Immunology, Infectious Diseases, Microbiology, Pathology, Pharmacology
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