Main description:

Because of the increasing burden of hepatitis C and fatty liver disease, there is an explosion in the prevalence of chronic liver failure and hence its complications. The onset of Hepatic Encephalopathy (HE) in these patients has a significant impact on the quality of life, morbidity and mortality. Unfortunately, the approach observed by most clinicians to this complex disorder is minimalistic.

This book provides a comprehensive review on pathophysiology and clinically important aspects in HE. Topics in basic physiology, nitrogen metabolism, new insights into pathogenesis and brain edema are covered in great detail. The authors have made a special effort by simplifying the complex aspects of pathogenesis and diagnosis so that it can be easily understood and applied clinically. This volume also focuses on recent developments regarding diagnoses of subtle forms of HE, also known as minimal or covert HE as well as on new treatments. Hepatic Encephalopathy will be of great value to gastroenterologists, hepatologists, pathologists, medical residents, fellows, internists and general practitioners who treat patients with hepatic encephalopathy.

Contents:

Ch. 1 Introduction, Nomenclature and Classification of Hepatic Encephalopathy

Kevin D. Mullen

Ravi K. Prakash

Section A: Pathogenesis

Ch. 2: Role of Ammonia in the Pathogenesis of Hepatic Encephalopathy

Jan Albrecht

Ch. 3: Neuro-inflammation in the Pathogenesis of Hepatic Encephalopathy

Roger Butterworth

Ch. 4: Inflammation and Hepatic Encephalopathy

Debbie Lindsay Shawcross

Shabnam S. Shabbir

Amit Singh Seyan

Ch. 5: Oxidative Stress in Hepatic Encephalopathy

Michael D. Norenberg

Arumugam R. Jayakumar

Ch. 6: The Role of Natural Benzodiazepines Receptor Ligands in Hepatic Encephalopathy

E. Anthony Jones

Kevin D. Mullen

Section B: Diagnosis

Ch. 7: Diagnosis of Overt Hepatic Encephalopathy

Karin Weissenborn

Ch. 8: Diagnosis of Minimal Hepatic Encephalopathy

Jennifer Y. Montgomery

Jasmohan S. Bajaj

Ch. 9: The Electroencephalogram in Hepatic Encephalopathy

Piero Amodio

Ch. 10: Brain Imaging in Hepatic Encephalopathy

Rita Garcia-Martinez

Juan Cordoba

Section C: Treatment

Ch. 11: Disaccharides in the treatment of hepatic encephalopathy

Praveen Sharma

Shiv Kumar Sarin

Ch. 12: Antibiotic Treatment for Hepatic Encephalopathy

Kevin D. Mullen

Ravi K. Prakash

Ch. 13: Ornithine phenylacetate: A novel strategy for the treatment of Hepatic Encephalopathy

Maria Jover-Cobos

Nathan A. Davies

Yalda Sharifi

Rajiv Jalan

Section D: Special Topics

Ch. 14: Sleep Disorders and Hepatic Encephalopathy

Sara Montagnese

Ch. 15: Hepatic Encephalopathy and Driving

Matthew R. Kappus

Jasmohan S. Bajaj

Ch. 16: Nutrition and Hepatic Encephalopathy

Manuela Merli

Michela Giusto

Oliviero Riggio

Ch. 17:Hepatic Encephalopathy in Patients with Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Martin Roessle

Wulf Euringer

Ch. 18: Quality of Life in Hepatic Encephalopathy

Jillian Kallman Price

Zobair M. Younossi

Ch. 19: Liver transplantation and Hepatic Encephalopathy

Dileep K. Atluri

Kevin D. Mullen

Ch. 20: Future of Hepatic Encephalopathy

Ravi K. Prakash

Kevin D. Mullen

Praveen Sharma

Shiv Kumar Sarin

Ch. 12: Antibiotic Treatment for Hepatic Encephalopathy

Kevin D. Mullen

Ravi K. Prakash

Ch. 13: Ornithine phenylacetate: A novel strategy for the treatment of Hepatic Encephalopathy

Maria Jover-Cobos

Nathan A. Davies

Yalda Sharifi

Rajiv Jalan

Section D: Special Topics

Ch. 14: Sleep Disorders and Hepatic Encephalopathy

Sara Montagnese

Ch. 15: Hepatic Encephalopathy and Driving

Matthew R. Kappus

Jasmohan S. Bajaj

Ch. 16: Nutrition and Hepatic Encephalopathy

Manuela Merli

Michela Giusto

Oliviero Riggio

Ch. 17:Hepatic Encephalopathy in Patients with Transjugular Intrahepatic Portosystemic Shunt (TIPS)

Martin Roessle

Wulf Euringer

Ch. 18: Quality of Life in Hepatic Encephalopathy

Jillian Kallman Price

Zobair M. Younossi

Ch. 19: Liver transplantation and Hepatic Encephalopathy

Dileep K. Atluri

Kevin D. Mullen

Ch. 20: Future of Hepatic Encephalopathy

Ravi K. Prakash

Kevin D. Mullen

Zobair M. Younossi

Ch. 19: Liver transplantation and Hepatic Encephalopathy

Dileep K. Atluri

Kevin D. Mullen

Ch. 20: Future of Hepatic Encephalopathy

Ravi K. Prakash

Kevin D. Mullen