Main description:

This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab.

Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.

Contents:

1. General Concepts of Pharmacodynamics for Anti-Infective Agents

Johan W. Mouton

2. In Vitro Pharmacodynamic Models to Evaluate Anti-Infective Pharmacodynamics

Warren Rose

3. Animal Models to Evaluate Anti-Infective Pharmacodynamics

Alexander J. Lepak and David R. Andes

4. Pharmacodynamic Issues in Antibiotic Combinations

Zackery P. Bulman, Ryan C. Dillon, Sarith M. Saju, Neang S. Ly, Gauri G. Rao, Phillip J. Bergen, Cornelia B. Landersdorfer, Alan Forrest, Juergen B. Bulitta, and Brian T. Tsuji

5. Methodologies for Protein Binding Determination in Anti-Infective Agents

Jatinder Kaur Mukker, Ravi Shankar Prasad Singh, and Hartmut Derendorf

6. Evaluation of Exposure-Response Relationships Using Clinical Data: Basic Concepts and Applications<

Sujata M. Bhavnani, Christopher M. Rubino, and Paul G. Ambrose

7. Toxicokinetics and Toxicodynamics of Anti-Infective Agents

David E. Nix

Part II: Pharmacodynamics of Antibacterial Agents

8. Pharmacodynamics of Fluoroquinolones

Ramy Elshaboury, Thomas Dilworth, and John Rotschafer

9. Aminoglycoside Pharmacodynamics

Dana R. Bowers, Amy N. Schilling, and Vincent H. Tam

10. Polymyxin Phar

macokinetics and Pharmacodynamics

Soon-Ee Cheah, Jian Li, Phillip J. Bergen, and Roger L. Nation

11. Vancomycin Pharmacodynamics: Optimal vs. Controversial

Ben M. Lomaestro

12. Pharmacodynamics of Lipoglycopeptides

Eric Wenzler, Siyun Liao, and Keith A. Rodvold

<13. Pharmacodynamics of Daptomycin

Eric Wenzler, Siyun Liao, and Keith A. Rodvold

14. Pharmacodynamics of Macrolides, Azalides, and Ketolides

Wonhee So and David P. Nicolau

Part III: Pharmacodynamics of Non-Antibacterial Agents

15. Antifungal Pharmacokinetics and

Pharmacodynamics

William Hope and David R. Andes

16. Pharmacokinetics and Pharmacodynamics of the Tuberculosis Drugs

Aline B. Barth, Eric F. Egelund, and Charles A. Peloquin

17. Pharmacodynamics of Antimalarial Agents

Rahul P. Bakshi and Theresa A. Shapiro

18. Pharmacodynamics of Antiviral Agents

Renee-Claude Mercier, Bernadette Jakeman, and Larry Pineda

19. Pharmacodynamics of Antiretroviral Agents

K

ajal B. Larson and Edward P. Acosta

Part IV: Pharmacodynamic Considerations and Special Populations

20. Implementing a Continuous or Prolonged Infusion Be

ta-Lactam Program in the Hospital Setting

Shawn H. MacVane, Nathaniel J. Rhodes, Marc H. Scheetz, and Joseph L. Kuti

21. Pharmacodynamic Considerations in Critically Ill Patients

Mahipal G. Sinnollareddy and Jason A. Roberts

22. Pharmacodynamic Considerations and Special Populations: Pediatrics

Jennifer Le and John S. Bradley

23. Pharmacodynamics and Obesity

Manjunath P. Pai

24. Drug Development Process and Regulatory Science

Evelyn J. Ellis-Grosse and Jogarao Gobburu

25. Antibiotic Stewardship an

d Applications of Pharmacodynamics

Elizabeth D. Hermsen and Lynne Fehrenbacher