Main description:

This detailed volume aims to introduce nanomaterials as a new therapeutic regimen in treating human diseases. Divided into four sections, it explores inorganic nanomaterials, organic nanomaterials, pharmaceutical properties of nanomaterials, and applications of nanomaterials in medicine. Several examples of inorganic and organic nanomaterials are provided to demonstrate how to design and develop nanomaterials for pharmacological purposes. The key pharmaceutical properties, including biocompatibility, tissue interaction, pharmaceutics, and pharmacokinetics of nanomaterials are discussed with a focus on the safety and pharmaceutical considerations of nanomaterials in translational development. The pharmacological applications of nanomaterials are depicted in treating various human diseases, including cancer, cardiovascular diseases, immune disorders, infectious diseases, gastrointestinal disorders, bone diseases, respiratory disorders, and drug delivery. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of specifics and practical advice that ensures a smooth transition into the lab.

Authoritative and enlightening, Nanomaterials in Pharmacology serves as an ideal guide to researchers investigating the potential benefits and risks of nanomaterials in pharmacology in order to avoid the pitfalls and to maximize the potential of this vital field of study.

Contents:

1. Synthetic Polymer-Based Nanomaterials

Swapnil S. Desale, Jinjin Zhang, and Tatiana K. Bronich

2. Cyclodextrin-Based Drug Carriers for Low Molecular Weight Drugs, Proteins, and Nucleic Acids

Taishi Higashi, Keiichi Motoyama, and Hidetoshi Arima

3. Development of Dendrimer-Based Nanomaterials for Diagnostic and Therapeutic Applications

Beibei Wang, Zheng-Rong Lu, and Mingqian Tan

4. Paving the Way Toward Translational Application of Virus-Based Nanoparticles (VNPs): Preclinical Evaluation of Their Biological Fates

Anna E. Czapar and Nicole F. Steinmetz

5. Gold Nanoparticles for Biomedical Applications: Synthesis and In Vitro Evaluation

Peter Chhour, Pratap C. Naha, Rabee Cheheltani, Barbara Benardo, Shaameen Mian, and David P. Cormode

6. Paramagnetic Nanoparticles

Randall Toy and Efstathios Karathanasis

7. Silica Nanomaterials

Katsuhiko Ariga and Qingmin Ji

8. Silicon Nano- and Microparticles

Chaofeng Mu and Haifa Shen

9. Biocompatibility of Nanomaterials

Yasuo Yoshioka, Kazuma Higashisaka, and Yasuo Tsutsumi

10. Nanoparticle-Tissue Interaction

Xiaohui Wu and Zheng-Rong Lu

11. Pharmaceutics of Nanoparticles

Masami Ukawa, Hidenori Ando, Taro Shimizu, and Tatsuhiro Ishida

12. Pharmacokinetic Properties of Nanomaterials

Makiya

Nishikawa

13. Cardiovascular Nanomedicine: Materials and Technologies

Anirban Sen Gupta

14. Gastrointestinal System

Yoshimine Fujii and Shinji Sakuma

15. Respiratory System

Kohsaku Kawakami

16. Depot Microcapsules Containing Biologic Nanoparticles and Cytoplasm-Responsive Nanocarriers for Nucleotides

Hiroaki Okada

17. Nanoparticulate Drug Delivery Systems to Overcome the Blood-Brain Barrier

Tatsuaki Tagami, Moeko Taki, and Tetsuya Ozeki

18. Transcutaneous Immunization Using Nano-Sized Drug Carriers

Momoko Kitaoka and Masahiro Goto

19. Nanomaterials for Treating Ocular Diseases

Guanping Yu, Amita Vaidya, Da Sun, and Zheng-Rong Lu

20. Nanomedicine for the Treatment of Musculoskeletal Diseases

Ke Ren, Xin Wei, Lingli Zhang, and Dong Wang

21. Synthetic Polymeric Nanoparticles for Immunomodulation

Jiaying Liu, Pallab Pradhan, and Krishnendu Roy

22. Nanomedicine and Infection

Takami Akagi and Mitsuru Akashi

23. Cancer Therapy with Nanotechnology-Based Drug Delivery Systems: Applications and Challenges of Liposome Technologies for Advanced Cancer Therapy

Ryo Suzuki, Daiki Omata, Yusuke Oda, Johan Unga, Yoichi Negishi, and Kazuo Maruyama