Main description:

This comprehensive book explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. It includes a basic study of cytokines and details the effects of cytokines on the immune system and in treating cancer. The book serves as both a primer and a starting point for a more detailed investigation of the role these biological regulators play.

Contents:

CYTOKINES IN HUMAN HEALTH: IMMUNOTOXICOLOGY, PATHOLOGY AND THERAPEUTIC APPLICATIONS

Robert V. House and Jacques Descotes, Editors
Table of Contents: Final

Preface (Robert V. House, DVC LLC)

Chapter 1: Introduction to cytokines as targets for immunomodulation (Theresa Whiteside)

Chapter 2: Cytokine measurement tools for immunotoxicology (Rob J. Vandebriel)

Chapter 3: The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions (Herve Lebrec and John Vasilakos)

Chapter 4: Microbial exploitation and subversion of the human chemokine network (James Pease)

Chapter 5: The use of cytokines in the identification and characterization of chemical allergens (Rebecca Dearman and Ian Kimber)

Chapter 6: Inflammatory cytokines and lung toxicity (Debra L. Laskin, Vasanthi R. Sunil, Robert J. Laumbach and Howard M. Kipen)

Chapter 7: Cytokine polymorphisms and relationship to disease (Berran Yucesoy, Victor Johnson, Michael Kashon and Michael Luster)

Chapter 8 : Effects of drugs of abuse on cytokine responses (Stephen B. Pruett)

Chapter 9: Preclinical approaches for safety assessment of cytokines (Peter T. Thomas and Melissa S. Beck-Westermeyer)

Chapter 10: The flu-like syndrome and cytokines (Jacques Descotes and Thierry Vial)

Chapter 11 : Cytokine-induced vascular leak syndrome (Roxana Baluna)

Chapter 12 : Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment (Pierre Miossec)

Chapter 13: Evaluation of antibodies in clinical trials of cytokines (Steven Swanson)

Chapter 14: Cytokines and pharmacokinetic drug interactions (Kenneth Renton)

Chapter 15 : Evaluation of the immunologic effects of cytokines administered to patients with cancer (Michael Robertson)

Chapter 16: Clinical adverse effects of cytokines on the immune system (Thierry Vial and Jacques Descotes)