Main description:

In Vitro Toxicology Systems brings together important issues and considerations needed in order to develop a workable, reliable, integrated testing strategy for the replacement of animals in toxicity testing regimes. This thorough volume includes sections on in vitro models for systemic organ toxicity, neurotoxicity, sensory organs, immunotoxicity and reproductive toxicity and addresses how stem cells may be used going forward. The book also tackles difficult areas of toxicology such as carcinogenicity and nanotoxicology, with additional chapters dedicated to kinetics, metabolism, and in vitro in vivo extrapolation. The book also addresses biological processes such as stress response pathways and mechanistic biomarkers and how these can be uncovered and measured using high content approaches.

Reliable and authoritative, In Vitro Toxicology Systems will be of benefit not only to students, scientists and regulators working in the field of chemical safety assessment but also to a wider scientific audience.

Contents:

Part I: Introduction

1. The Past, Present and Future of Chemical Risk Assessment

Alice Limonciel

Part II: Systemic Organ Toxicity

2. In Vitro Systems for Hepatotoxicity Testing

Jan G. Hengstler, Seddik Hammad, Ahmed Ghallab, Raymond Reif and Patricio Godoy

3. In Vitro Methods for Cardiotoxicity Testing

Vaibhav Shinde, Umesh Chaudhari, Isaia Sotiriadou, Jurgen Hescheler and Agapios Sachinidis

4. Renal Cell Culture

Paul Jennings, Lydia Aschauer, Anja Wilmes and Gerhard Gstraunthaler

5. Cellular Models for In Vitro Lung Toxicology

Oliver H. Wittekindt

Part III: Neurotoxicity

6. In Vitro Developmental Neurotoxicity Testing: Relevant Models and Endpoints

Anna Bal-Price and Helena T. Hogberg

7. Blood Brain Barrier In Vitro Models and Their Applications in Toxicology

Anaelle Fabulas-Da Costa, Christophe Landry, Lucie Dehouck, Emmanuel Sevin, Marie-Pierre Dehouck, Romeo Cecchelli and Maxime Culot

Part IV: Sensory Organ Models

8. Ocular Toxicity

Chantra Eskes, Erwin van Vliet, Michael Schaffer and Valerie Zuang

9. In Vitro Models for Ototoxic Research

Jochen Schacht and Michael G. Leitner

Part V: Other Organs and Aspects

10. Dermal Toxicity: Skin Sensitization

David Basketter and Silvia Casati

11. Immunotoxicity

Thomas Hartung

12. Reproductive Toxicity

Giovanna Lazzari and Cesare Galli

13. Evaluating Endocrine Disruption In Vitro

Patrick J. Devine

14. Current and Emerging In Vitro Methods for Genotoxicity and Carcinogenicity

Federica Madia, Pascal Phrakonkham, and Raffaella Corvi

Part VI: The Use of Stem Cells

15. Use of Induced Pluripotent Stem Cells in Drug Toxicity Screening

Caroline Rauch, Paul Jennings, and Anja Wilmes

16. Human Stem/Progenitor Cell-Based Assays for Neurodevelopmental Toxicity Testing

Ellen Fritsche

Part VII: Techniques and Markers

17. High Content Imaging Approaches for In Vitro Toxicology

Marianne Uteng, Davide Germano, Kamal Kumar Balavenkatraman, Francois Pognan, and Armin Wolf

18. Application of Omics Technologies to In Vitro Toxicology

Nina V. Balmer, Tyna Dao, Marcel Leist, Kinga Vojnits, Tanja Waldmann, Liang Zhao, Helena T. Hogberg, and Erwin van Vliet

19. Stress Response Pathways

Martin O. Leonard, Alice Limonciel, and Paul Jennings

20. Translational Biomarkers, In Vitro and In Vivo

Anja Wilmes, Alice Limonciel, Martin O. Leonard, and Paul Jennings

Part VIII: Challenges and Considerations

21. Nanotoxicology

Agnieszka Kinsner-Ovaskainen, Pascal Colpo, Jessica Ponti and Francois Rossi

22. Consideration of Metabolism in In Vitro Cellular Systems

Olavi Pelkonen, Jorma T. Ahokas, Jukka Hakkola, and Miia Turpeinen

23. In Vitro Approaches to Predictive Biokinetics

Bas J. Blaauboer

24. Extrapolating In Vitro Results to Predict Human Toxicity

Nadia Quignot, Jeremy Hamon, and Frederic Y. Bois

25. Considerations in the Development of In Vitro Toxicity Testing Methods Intended for Regulatory Use

Sandra Coecke, Gerard Bowe, Anne Milcamps, Camilla Bernasconi, Ann-Charlotte Bostroem, Gilles Bories, Salvador Fortaner, Jean-Michel Gineste, Varvara Gouliarmou, Ingrid Langezaal, Roman Liska, Emilio Mendoza, Siegfried Morath, Vittorio Reina, Iwona Wilk-Zasadna and Maurice Whelan.