Main description:

The volume includes 75 papers which were presented at the Third International Conference on Intracerebral Hemorrhage, held in Rancho Mirage, California, in March 2010. The topics treated include animal models, pathophysiology of cerebral hemorrhage, experimental treatment for cerebral hemorrhage, cerebral hemorrhage clinical manifestations, prognosis of cerebral hemorrhage, and clinical management. The articles represent the recent advances in hemorrhagic brain injury research presented by highly respected laboratories around the world.

Contents:

Cerebral hemorrhage animal models: Q. Ma, N. Khatibi, H. Chen, J. Tang, J. H. Zhang: History of Preclinical Models of Intracerebral Hemorrhage. - A. Manaenko, H. Chen, J. H. Zhang, J. Tang Comparison of different preclinical models of intracerebral hemorrhage. - H. Chen, J. H. Zhang: Cerebral amyloid angiopathy-related microhemorrhages in Alzheimer's disease: a review of investigative animal models. - B. Orakcioglu, M. Kentar, Y. Uozumi, E. Santos, P. Schiebel, A. Unterberg, O.W. Sakowitz: Multiparametric characterisation of the perihemorrhagic zone in a porcine model of lobar ICH. - J. Tang, J. Ai, R. Loch Macdonald: Developing a model of chronic subdural hematoma. - Y. Tada, Y. Kanematsu, M. Kanematsu, Y. Nuki, E. I Liang, K. Wada, H. Makino, T. Hashimoto: A mouse model of intracranial aneurysm-technical considerations. - T. Lekic, R. P. Ostrowski, H. Suzuki, A. Manaenko, W. Rolland, N. Fathali, J. Tang, J. H. Zhang: The postpartum period of pregnancy worsens brain injury and functional outcome after cerebellar hemorrhage in rats. - T. Tsubokawa, H. Joshita, Y. Shiokawa, H. Miyazaki: Hyperglycemia and hemorrhagic transformation of cerebral infarction: a macroscopic hemorrhagic transformation rat model. - Y. Xing, X. Jiang, Y. Yang, G. Xi: Hemorrhagic transformation induced by acute hyperglycemia in a rat model of transient focal ischemia. -T. Lekic, A. Manaenko, W. Rolland, J. Tang, J. H. Zhang: A novel preclinical model of germinal matrix hemorrhage using neonatal rats.

Pathophysiology of cerebral hemorrhage: J. Lok, W. Leung, S. Murphy, W. Butler, N. Noviski, E. H. Lo: Intracranial hemorrhage - mechanisms of secondary brain injury. - R.F. Keep, G. Xi, Y. Hua, J. Xiang: Clot formation, vascular repair and hematoma resolution after ICH, a coordinating role for thrombin?. - D.-Z. Liu, F. R Sharp: The dual role of src kinases in intracerebral hemorrhage. - H. Kim, H. Su, S. Weinsheimer, L. Pawlikowska, W. L. Young: Brain arteriovenous malformation pathogenesis: a response-to-injury paradigm. - N. Fathali, N. H. Khatibi, R. P. Ostrowski, J. H. Zhang: The evolving landscape of neuroinflammation after neonatal hypoxia-ischemia. - F. Zhao, S. Song, W. Liu, R. F. Keep, G. Xi, Y. Hua: Red blood cell lysis and brain tissue-type transglutaminase upregulation in a hippocampal model of intracerebral hemorrhage. - X. Zhao, S. Song, G. Sun, J. Zhang, R. Strong, L. Zhang, J. C. Grotta, J. Aronowski: Cytoprotective role of haptoglobin in brain after experimental intracerebral hemorrhage. - Y. Gong, Y. He, Y. Gu, R. F. Keep, G. Xi, Y. Hua: Effects of aging on autophagy after experimental intracerebral hemorrhage
Z. Ye, Q. Xie, G. Xi, R. Keep, Y. Hua: Effects of gender on heart injury after intracerebral hemorrhage in rats
Y. Gu, Y. Hua, Y. He, L. Wang, H. Hu, R. F. Keep, G. Xi: Iron accumulation and DNA damage in a pig model of intracerebral hemorrhage
H. Suzuki, T. Sozen, Y. Hasegawa, W. Chen, K. Kanamaru, W. Taki, J. H. Zhang: Subarachnoid hemorrhage causes pulmonary endothelial cell apoptosis and neurogenic pulmonary edema in mice
Y. He, Y. Hua, R. F. Keep, W. Liu, M. M. Wang, G. Xi: Hemoglobin expression in neurons and glia after intracerebral hemorrhage

Experimental treatment for cerebral hemorrhage
P. R. Gigante, G. Appelboom, B. Y. Hwang, R. M. Haque, M. L. Yeh, A. Ducruet, C. P. Kellner, J. Gorski, S. E. Keesecker, E. Sander Connolly, Jr.: Isoflurane preconditioning affords functional neuroprotection in a murine model of intracerebral hemorrhage
R. Ayer, V. Jadhav, T. Sugawara, J.H. Zhang: The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage
J. Tong, J. M. Latzman, J. Rauch, D. S. Zagzag, J. H. Huang, U. Samadani: Sonic hedgehog agonist fails to induce neural stem cell precursors in a porcine model of experimental intracranial hemorrhage
A. Manaenko, T. Lekic, J. H. Zhang, J. Tang: NC1900, An arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model
A. Manaenko, N. Fathali, S. Williams, T. Lekic, J. H. Zhang, J. Tang: Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage
L. Kueppers-Tiedt, A. Manaenko, D. Michalski, A. Guenther, C. Hobohm, A. Wagner, J. H. Zhang, D. Schneider: Combined systemic thrombolysis with Alteplase and early hyperbaric oxygen therapy in experimental embolic stroke in rats - relationship to functional outcome and reduction of structural damage
L. H. Sansing, T. H. Harris, S. E. Kasner, C. A. Hunter, K. Kariko: Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage
A. Manaenko, T. Lekic, Q. Ma, R. P. Ostrowski, J. H. Zhang, J. Tang: Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage
T. Hatakeyama, M. Okauchi, Y. Hua, R. F. Keep, G. Xi: Deferoxamine reduces cavity size in the brain after intracerebral hemorrhage in aged rats
A. Manaenko, N. Fathali, N. H. Khatibi, T. Lekic, K. J. Shum, R. Martin, J. H. Zhang, J. Tang: Post-treatment with Sr49059 improve outcomes following an intracerebral hemorrhagic stroke in mice
H. Hu, L. Wang, M. Okauchi , R. Keep, G. Xi, Y. Hua: Deferoxamine affects heat shock protein expression in heart after intracerebral hemorrhage in aged rats
T. Lekic, A. Manaenko, W. Rolland, K. Virbel, R. Hartman, J. Tang, J. H. Zhang: Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats
N. H. Khatibi, L. K. Lee, Y. Zhou, W. Chen, W. Rolland, N. Fathali, R. Martin, R. Applegate, G. Stier, J. H. Zhang: Endothelin receptor-A (Eta) inhibition fails to improve neonatal hypoxic-ischemic brain injury in rats
W. B. Rolland II, A. Manaenko, T. Lekic, Y. Hasegawa, R. Ostrowski, J. Tang, J. H. Zhang: FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice
S. Song, H. Hu, Y. Hua, J. A. Wang, G. Xi: Thrombin preconditioning reduces iron-induced brain swelling and brain atrophy
N. H. Khatibi, V. Jadhav, S. Charles, J. Chiu, J. Buchholz, J. Tang, J. H. Zhang: Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats
H. Suzuki, Y. Hasegawa, R. Ayer, T. Sugawara, W. Chen, T. Sozen, K. Kanamaru, W. Taki, J. H. Zhang: Effects of recombinant osteopontin on blood-brain barrier disruption after subarachnoid hemorrhage in rats
T. Lekic, A. Manaenko, W. Rolland, N. Fathali, M. Peterson, J. Tang, J. H. Zhang: Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats
D. Westra, W. Chen, R. Tsuchiyama, A. Colohan, J. Zhang: Pretreatment with normobaric and hyperbaric oxygenation worsens cerebral edema and neurologic outcomes in a murine model of surgically induced brain injury
T. Lekic, A. Manaenko, W. Rolland, R. P. Ostrowski, K. Virbel, J. Tang, J. H. Zhang: Beneficial effect of hyperbaric oxygenation after neonatal germinal matrix hemorrhage
H. Hu, S. Yamashita, S. Song, Y. Hua, R. F. Keep, G. Xi: Thrombin preconditioning attenuates iron-induced neuronal death
N. H. Khatibi, V. Jadhav, M. Saidi, W. Chen, R. Martin, G. Stier, J. Tang, J. H. Zhang: Granulocyte-colony stimulating factor treatment provides neuroprotection in surgically induced brain injured mice
Q. Xie, G. Wu, G. Xi, R. Keep, Y. Hua: Tamoxifen treatment for intracerebral hemorrhage
N. H. Khatibi, V. Jadhav, B. Matus, N. Fathali, R. Martin, R. Applegate, J. Tang, J. H. Zhang: Prostaglandin E2 Ep1 receptor inhibition fails to provide neuroprotection in surgically-induced brain injured mice
N. Jafarian, R. Ayer, J. Eckermann, N. Jafarian, R.L. Applegate II, G. Stier, R. Martin, J. Tang, J.H. Zhang: Mucosal tolerance to brain antigens preserves endogenous TGF -1 and improves neurological outcomes following experimental craniotomy
Z. Chen, G. Xi, Y. Mao, R. Keep, Y. Hua: Effects of progesterone and testosterone on ICH-induced brain injury in rats
W. Guan, A. Kozak, S. C. Fagan: Drug repurposing for vascular protection after acute ischemic stroke
M. Chau, D. Chen, L. Wei: Erythropoietin attenuates inflammatory factors and cell death in neonatal rats with intracerebral hemorrhage
W. Liu, O. Chen, C. Chen, B. Wu, J. Tang, J. H. Zhang: Protective effects of hydrogen on fetal brain injury during maternal mypoxia

Cerebral hemorrhage clinical manifestations
K. Jin, X. Mao, L. Xie, D. A. Greenberg: Neuroglobin expression in human arteriovenous mnalformation and intracerebral hemorrhage
X. Li, J. H. Zhang, X. Qin: Intracerebral hemorrhage and meteorological factors in Chongqing, in the Southwest of China
J. Feng, J. H. Zhang, X. Qin: Timing pattern of onset in patients with hypertensive intracerebral hemorrhage
F. Jiang, J. H. Zhang, X. Qin: "Weekend Effects" in patients with intracerebral hemorrhage
Y. Kong, Y. Wang, J. H. Zhang, X. Wang, X. Qin: Disparities in medical expenditure and outcomes among patients with intracranial hemorrhage associated with different insurance status in southwestern China
Z. Guo, T. Wang, J. H. Zhang, X. Qin: Clinical analysis on electrolyte imbalance in thalamic hemorrhage within 24 hours after admission
T. Tao, T. Wang, J. H. Zhang, X. Qin: Characteristics of pulse pressure parameters in acute intracerebral hemorrhage patients
Q. Liu,Y. Ding, H. Lei, J. Zhang: Electrocardiographic abnormalities in patients with intracerebral hemorrhage
Q. Liu, Y. Ding, H. Lei, J. Zhang: Electrocardiogram change of acute subarachnoid hemorrhagic patients
G. Huo, Q. Feng, M. Tang, D. Li: Diagnosis and treatment of hemorrhagic pituitary adenomas<
X. Wang, Y. Kong, H. Chen, J. H Zhang, Y. Wang: Characteristics of acute cerebral hemorrhage with regard to lipid metabolism and glycometabolism among different age groups

Prognosis of cerebral hemorrhage
L. H. Keong, A. R. I. Ghani, M. S. Awang, S. Sayuthi, B. Idris, J. M. Abdullah: The role of high augmentation index in spontaneous intracerebral hemorrhage to prognosticate mortality
G. Li, Xinyue Qin, G. Pen, W. Wu, J. Yang, Q. Yang: Effect of minimally invasive aspiration in treatment of massive intracerebral hemorrhage
Y. Wang, X. Wang, Y. Kong, F. Li, H. Chen: Retrospective analysis of the predictive effect of coagulogram on the prognosis of Intracerebral hemorrhage
X. Hu, J. H. Zhang, X. Qin: Risk factors of early death in patients with hypertensive intracerebral hemorrhage during hospitalization
Y. Wang, T. Wang, J. H. Zhang, X. Qin: Effects of early serum glucose levels on prognosis of patients with acute intracerebral hemorrhage
Q. Li, X. Qin, J. Zhang, J. Yang: The prognosis study of 324 cases with spontaneous intracerebral hemorrhage in Chongqing , China
H. Chen, F. Li , X. Wang, Y. Kong, Y. Wang: Retrospective analysis of the predictive effect of routine biochemical results on the prognosis of Intracerebral hemorrhage

Clinical Management
J. Bartek Jr., J. Hansen-Schwartz, J. Degn, B. Romner, K.L. Welling, W. Fischer Alteplase (rtPA) treatment of intraventricular haematoma (IVH): Safety of an efficient methodological approach for rapid clot removal
N. Shimamura, A. Munakata, M. Naraoka, T. Nakano, H. Ohkuma: Decompressive hemi-craniectomy is not necessary to rescue supratentorial hypertensive intracerebral hemorrhage patients: Consecutive single center experience.
A. Husin, J. M. Abdullah: Intravascular hypothermia for acute haemorrhagic stroke: a pilot study
P. A. Bouz, W. D. Johnson: Use of intralesional tPA in spontaneous intracerebral hemorrhage retrospective analysis
Y. Hasegawa, S. Yano, T. Sakurama, Y. Ohmori, T. Kawano, M. Morioka, H. Chen, J- H Zhang, and J. Kuratsu: Endoscopic surgical treatment for pituitary apoplexy in three elderly patients over the age of 80
L. Ran, N. H. Khatibi, X. Qin, J. H. Zhang: Proton pump inhibitor prophylaxis increases the risk of nosocomial pneumonia in patients with an intracerebral hemorrhagic stroke