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MORE ABOUT THIS BOOK
Main description:
The initial identification of the Adenomatous polyposis eoli (Ape) gene as the site of mutations in familial adenomatous polyposis (FAP) was described in 1 1992. ,2 A causal relationship between Ape mutations and intestinal tract tumours was confirmed three years later with the establishment ofthe Min mouse model) These mice are heterozygous forApe and develop numerous intestinal tumours that mimic FAP. Subsequently, Ape has emerged as the most commonly mutated gene in colorectal cancerwith reports varying between 50-80% ofsporadic tumours car- rying such mutations. The search for how mutations in Ape initiate and/or support progression oftumours in the intestinal tract has revealed that the Ape protein is a multifunctionalparticipant in a diverse array ofcellular functions. By collecting and assembling the chapters inthisbook, we aimed toprovide an overview of the diverse functions performed by the Ape protein. As summarised in a short final chapter by Trainer,heterozygosityofApe leads to a number ofextracolonic manifestations that further support this emerging picture ofthe Ape protein as an active contributor to many different cellular functions.
The first recognised function of Ape was its role in Wnt signalling. o This function is one of the driving forces for how mutations in Ape ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan.
Contents:
1. APC and ss-Catenin Degradation
Jennifer Kennell and Kenneth M. Cadigan 2. Nuclear APC
Kristi L. Neufeld 3. APC in Cell Migration
Sandrine Etienne-Manneville 4. The APC-EB1 Interaction
Ewan E. Morrison 5. The Role of APC in Mitosis and in Chromosome Instability
Christine M. Caldwell and Kenneth B. Kaplan 6. Role of APC and its Binding Partners in Regulating Microtubules in Mitosis
Shirin Bahmanyar, W. James Nelson and Angela I.M. Barth 7. The Adenomatous Polyposis Coli Tumor Suppressor and Wnt Signaling in the Regulation of Apoptosis
Hassina Benchabane and Yashi Ahmed 8. APC and Its Modifiers in Colon Cancer
Lawrence N. Kwong and William F. Dove 9. Tissue-Specific Tumour Suppression by APC
Owen Sansom 10. Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli
Alison H. Trainer
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: September, 2009
Pages: 148
Weight: 355g
Availability: Available
Subcategories: General Issues
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