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MORE ABOUT THIS BOOK
Main description:
The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.
Feature:
Illustrates the finding that the insect central nervous system is extremely rich in acetylcholine receptors that have a predominantly nicotinic pharmacology
Demonstrates that several amino acids that account for ligand binding domain are conserved in the insect nicotinic receptor subunit
Explores the involvement of insect nicotinic receptors in learning and memory processes using the honeybee as insect model
Contents:
1. Identification of Cholinergic Synaptic Transmission in the Insect Nervous System
Steeve Hervé Thany, Hélène Tricoire?Leignel and Bruno Lapied
Abstract
Introduction
Insect Acetylcholinesterase: Catalytic Properties and Tissue Distribution
Identification and Tissue Distributions of Choline Acetyltransferase in Insects
Identification of Native Neuronal Nicotinic Acetylcholine Receptors
Insect Nicotinic Acetylcholine Receptors Subunit Localizations
Conclusion
2. The Evolution of Pentameric Ligand?Gated Ion Chanels
Joseph A. Dent
Abstract
Introduction
Structure: pLGICs share an underlying structure
Function: pLGICs Can Mediate Many Types of Ionotropic Neurotransmission
Evolution: pLGIC Diversity Appears To Be Ancient
What Good is pLGIC Diversity?
3. Diversity of Insect Nicotinic Acetylcholine Receptor Subunits
Andrew K. Jones and David B. Sattelle
Abstract
Introduction
Nicotinic Acetylcholine Receptors (nAChRs)—Structure and Function
Nicotinic Acetylcholine Receptors—Roles in Human Disease and as Drug Targets
Insect Nicotinic Acetylcholine Receptors—Targets for Pest Control
The nAChR Gene Family in a Genetic Model Organism, the Fruitfly Drosophila melanogaster
Characterisation of Complete nAChR Gene Families from Five Insect Species Spanning Over 300 Million Years of Evolution
RNA Editing and Alternative Splicing Broadens the Insect Nicotinic “Recepterome”
Conclusion and Prospects
4. Identification of Critical Elements Determining Toxins and Insecticide Affinity, Ligand Binding Domains and Channel Properties
Hélène Tricoire?Leignel and Steeve Hervé Thany
Abstract
Introduction
Toxins—nAChRs Interaction
Insecticides—nAChRs Interaction: Residues Involved in Neonicotinoid Selectivity
Insecticides—nAChRs Interaction: Residues Involved in Neonicotinoid Binding
Amino?Acid Involved in Ionic Selectivity
Conclusion
5. Electrophysiological Studies and Pharmacological Properties of Insect
Native Nicotinic Acetylcholine Receptors
Steeve HervéThany
Abstract
Introduction
Pharmacological Profiles of Native Nicotinic Receptors Associated to Specific Neurons
Contribution of ‘Mixed’ Nicotinic/Muscarinic Receptor to the Complexity
of Native Nicotinic Receptors
Ca2+ and Ca2+ Pathways as Intracellular Regulators of Insect Neuronal
Nicotinic Receptors
Other Modulators of Insect Native Nicotinic Acetylcholine Receptors
Conclusion
6. Characterisation of Insect Nicotinic Acetylcholine Receptors by Heterologous Expression
Neil S. Millar and Stuart J. Lansdell
Abstract
Introduction
Characterization of Insect nAChRs by Heterologous Expression
Characterization of Hybrid nAChRs
Characterization of Chimeric nAChR Subunits
Co?Expression of Molecular Chaperones
Pharmacological Properties of Recombinant nAChRs
Conclusion
7. Neonicotinoid Insecticides: Historical Evolution and Resistance Mechanisms
Steeve Hervé Thany
Abstract
Introduction
Nicotine, Nicotinoids and Insecticidal Activities
Neonicotinoid Insecticides
Development of Novel Neonicotinoid Insecticides
Multiple Origins of Insect Resistance to Neonicotinoid Insecticides
Conclusion
8. Ecotoxicity of Neonicotinoid Insecticides to Bees
Axel Decourtye and James Devillers
Abstract
Introduction
Effects on Survival
Behavioral Effects
Conclusion
9. State of the Art on Insect Nicotinic Acetylcholine Receptor Function in Learning and Memory
Monique Gauthier
Abstract
Introduction
Role of ACh and Nicotinic Acetylcholine Receptors in Insect Behavior
Role of Nicotinic Acetylcholine Receptors in Learning and Memory in the Honeybee
Conclusion and Outlook: Using RNA Interference to Create Reversible
Mutant Honeybees for Memory
Index
PRODUCT DETAILS
Publisher: Springer (Springer New York)
Publication date: May, 2010
Pages: 138
Availability: Not available (reason unspecified)
Subcategories: General Issues
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