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Main description:
Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.
Contents:
Lipid Rafts, Caveolae and GPI-Linked Proteins.- Caveolae and the Regulation of Endocytosis.- Caveolin-1: Role in Cell Signaling.- Regulation of eNOS in Caveolae.- Recent Developments in the Interactions Between Caveolin and Pathogens.- Caveolin-1 and Breast Cancer: A New Clinical Perspective.- Caveolin-1 and Prostate Cancer Progression.- Caveolins and Caveolae, Roles in Insulin Signalling and Diabetes.- Atherosclerosis, Caveolae and Caveolin-1.- Caveolins and Heart Diseases.- Caveolins and Lung Function.
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: January, 2012
Pages: 204
Weight: 580g
Availability: Available
Subcategories: Anatomy, General Issues
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