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MORE ABOUT THIS BOOK
Main description:
This book attempts to analyze the latest discoveries in sphingolipid biology and how the alteration of their metabolism leads to altered signaling events and to the development of pathobiological disorders, such as cancer, cardiovascular diseases, asthma, diabetes, inflammation and infectious diseases.
Contents:
1. An Overview of Sphingolipid Metabolism: From Synthesis to Breakdown
Christopher R. Gault, Lina M. Obeid and Yusuf A. Hannun
Abstract
Sphingolipid Properties in Membranes
De Novo Synthesis in the ER
Ceramide Transport from the ER to the Golgi
Synthesis of Complex Sphingolipids
Ceramide Kinase and Ceramide?1?Phosphate
Catabolizing Complex Sphingolipids and Sphingomyelins into Ceramide
The Catabolism of Ceramides and the Final Common Breakdown Pathway
Conclusion
2. Sphingolipid Transport
Laura Riboni, Paola Giussani and Paola Viani
Abstract
Introduction
Intramembrane Sphingolipid Movements
Intermembrane Sphingolipid Transport
Conclusion
3. Sphingolipid Analysis by High Performance Liquid Chromatography?Ta ndem Mas Spectrometry (HPLC?MS/MS)
Jacek Bielawski, Jason S. Pierce, Justin Snider, Barbara Rembiesa, Zdzislaw M. Szulc and Alicja Bielawska
Abstract
Introduction
Sphingolipids: Structure and Composition
LC?MS Methods for Detection and Analysis of Bioactive Sphingolipids
Lipidomic Approach
Sample Preparation
Analysis of Intact Sphingolipids by Mass Spectrometry
Mechanism of Electrospray Ionization Mass Spectrometry (ESI/MS)
MS Scan Modes
Specific Scan Modes for MS/MS Instrumentation
Sphingolipid Identification
HPLC?MS/MS Methodology
Quantitation
Selection of Internal Standards (ISs)
Quantitative Calibration
Data Handling
Alternative Methodology
Conclusion
4. Ceramide Synthases: Roles in Cell Physiology and Signaling
Johnny Stiban, Rotem Tidhar and Anthony H. Futerman
Abstract
Introduction
Fatty Acid Specificity, Kinetics and Tissue Distribution
Inhibitors
Posttranslational Modifications
Membrane Topology
Why Are There So Many Mammalian CerS?
Roles of CerS in Signal Transduction and Disease
Conclusion
5. Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family
Joost C.M. Holthuis and Chiara Luberto
Abstract
Sphingomyelin Biosynthesis: An Historical Perspective
The Multigenic Sphingomyelin Synthase (SMS) Family
Cellular Functions of SMS FamilyMembers
Conclusion
6. Ceramide in Stress Response
Mariana N. Nikolova?Karakashian and Krassimira A. Rozenova
Abstract
Introduction
Chemical Structure and Biophysical Properties of Ceramide
Changes in Ceramide Mass During Stress
Mechanisms for Ceramide Generation During Stress
Mechanisms of Ceramide Effects on Cellular Functions
Conclusion
7. Animal Models for Studying the Pathophysiology of Ceramide
Toshihiko Kawamori
Abstract
Introduction
Sphingosine Kinase 1/2
Ceramidases
Sphingomyelinases (SMase) and Sphingomyelin Synthases (SMS)
S1P Lyase
The Other GEM for Sphingolipid?Related Enzymes
Conclusion
8. Ceramide 1?Phosphate in Cell Survival and Inflamatory Signaling
Antonio Gomez?Munoz, Patricia Gangoiti, Maria H. Granado, Lide Arana and Alberto Ouro
Abstract
Introduction
Ceramide 1?Phosphate Synthesis and Degradation
Ceramide 1?Phosphate: A Key Regulator of Cell Growth and Survival
Ceramide 1?Phosphate and the Control of Inflammatory Responses
Ceramide 1?Phosphate Mediates Macrophage Migration
Conclusion
9. Ceramide?1?Phosphate in Phagocytosis and Calcium Homeostasis
Vania Hinkovska?Galcheva and James A. Shayman
Abstract
Ceramide?1?Phosphate in Phagocytosis
Ceramide?1?Phosphate as a Regulator of Calcium Homeostasis
Conclusion
10. Extracellular and Intracellular Actions of Sphingosine?1?Phosphate
Graham M. Strub, Michael Maceyka, Nitai C. Hait, Sheldon Milstien and Sarah Spiegel
Abstract
Introduction
Sphingolipid Metabolism
Sphingosine Kinases
Evidence for Intracellular Targets of S1P
Implications, Future Directions, and Conclusion
11. Glucosylceramide in Humans
Maria C. Messner and Myles C. Cabot
Abstract
Introduction
Glucosylceramide Synthesis and Degradation
Multiple Functions of Glucosylceramide
Conclusion
12. Gangliosides as Regulators of Cell Membrane Organization and Functions
Sandro Sonnino and Alessandro Prinetti
Abstract
Introduction
Segregation of Membrane Lipids and Detergent?Resistant Membrane Domains
Lipid
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: August, 2010
Pages: 313
Weight: 675g
Availability: Available
Subcategories: General Issues, Pharmacology, Physiology
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