(To see other currencies, click on price)
MORE ABOUT THIS BOOK
Main description:
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.
Contents:
CONTENT Contents xiii PREFACE ........................................................................................................... vii 1. MOLECULAR MECHANISMS OF AXONAL GROWTH ........................ 1 Celine Bouquet and Fatiha Nothias Introduction .........................................................................................................................1 The Neuronal Growth Cone and its Cytoskeletal Organization ..................................... 1 Mechanisms of Axonal Elongation ..................................................................................... 6 Regulation of the Cytoskeleton by Extracellular Cues, Role of Rho-GTPases .................................................................................................. 7 Growth Cone of Regenerating Axons .............................................................................. 10 2. NETRINS AND THEIR RECEPTORS........................................................ 17 Simon W. Moore, Marc Tessier-Lavigne and Timothy E. Kennedy Introduction .......................................................................................................................17 Netrin Structure .................................................................................................................19 Functional Roles for Netrins during Nervous System Development ............................21 Netrin Signal Transduction...............................................................................................22 Netrin in the Adult Nervous System ................................................................................ 25 Conclusion and Perspectives ............................................................................................26 3. EPH RECEPTORS AND EPHRIN LIGANDS IN AXON GUIDANCE........................................................................ 32 Michael Reber, Robert Hindges and Greg Lemke Introduction .......................................................................................................................32 Molecular Structure .......................................................................................................... 32 Mechanisms of Signal Transduction ................................................................................ 34 Functional Implication during Nervous System Development ..................................... 39 Conclusion and Perspectives ............................................................................................44 4. ROLE OF SEMAPHORINS DURING AXON GROWTH AND GUIDANCE ................................................................................ 50 Eric Koncina, Lise Roth, Bertand Gonthier and Dominique Bagnard Introduction .......................................................................................................................50 Functional Roles of Semaphorins during Axon Guidance ............................................. 50 Receptors of Secreted-Semaphorins: The Neuropilins .................................................. 52 Receptors of Transmembrane-Semaphorins: The Plexin Family .................................53 Other Receptors Associated with Semaphorin Signaling .............................................. 54 Intracellular Signal Transduction ....................................................................................56 Conclusion .......................................................................................................................... 59 xiv Contents 5. SLITS AND THEIR RECEPTORS .............................................................. 65 Alain
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: January, 2008
Pages: 186
Weight: 515g
Availability: Available
Subcategories: Anatomy, General Issues, Neuroscience, Pharmacology
Publisher recommends
From the same series
