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MORE ABOUT THIS BOOK
Main description:
This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990's. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.
Contents:
Chapter 1 - Gene Therapies for Hepatitis C Virus - Monique M.A. Verstegen, Qiuwei Pan and Luc J.W. van der Laan
Chapter 2 - Recent Advances in Use of Gene Therapy to Treat Hepatitis B Virus Infection - Kristie Bloom, Abdullah Ely and Patrick Arbuthnot
Chapter 3 - U1interference (U1i) for antiviral approaches - Lorea Blazquez and Puri Fortes
Chapter 4 - Gene therapy strategies to block HIV-1 replication by RNA interference - Elena Herrera-Carrillo and Ben Berkhout
Chapter 5 - HIV and Ribozymes - Robert J. Scarborough and Anne Gatignol
Chapter 6 - Editing CCR5: a novel approach to HIV gene therapy - Tatjana Cornu, Claudio Mussolino, Kristie Bloom and Toni Cathomen
Chapter 7 - Synthetic DNA approach to Cytomegalovirus vaccine/immune therapy - Stephan J. Wu, Daniel O. Villarreal, Devon J. Shedlock and David B. Weiner
Chapter 8 - Vector-mediated antibody gene transfer for infectious diseases - Bruce C. Schnepp and Philip R. Johnson
Chapter 9 - HIV latency and the non-coding RNA therapeutic landscape - Sheena Saayman, Thomas C. Roberts, Kevin V. Morris and Marc S. Weinberg
Chapter 10 - C peptides as entry inhibitors for gene therapy - Lisa Egerer, Hans-Peter Kiem and Dorothee von Laer
Chapter 11 - Aptamer-siRNA chimeras for HIV - Mayumi Takahashi, John C. Burnett and John J. Rossi
PRODUCT DETAILS
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: March, 2015
Pages: 250
Weight: 5486g
Availability: Available
Subcategories: Counselling & Therapy, General Issues, Genetics, Immunology
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