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Histophysiology of the Immune System

The Life History, Organization, and Interactions of Its Cell Populations

Series: Advances in Experimental Medicine and Biology

by Sigbjorn Fossum, Bent Rolstad and Sigbjørn Fossum

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Main description:

The 9th International Conference on Lymphatic Tissues and Germinal Centres in Immune Reactions was held in Oslo, 9-14 August, 1987. These conferen ces, by the regular devotees just referred to as the germinal centre con ferences or GCC, have been held regularly at roughly three-year intervals since 1966. The credo of these conferences is "in vivo veritas", signifying that investigating components, like molecules and cells, only gives partial truth. The components must ultimately be explored in their natural con text, to see how they interact with other parts and are integrated to a whole. To the biologist it is obvious that the world must be investigated at many different levels of organization. At each level the patterns observed represent just some of many possible ways of putting together the elements of the lower levels. These patterns are not predetermined, but the results of evolution, i.e. of a history in which stochastic processes play a major role. The organic world can therefore not be torn apart and then reconstructed from basic principles alone. This realization is often expressed as the whole being more than the sum of its parts.

Contents:

A. Symposium on Surface Molecules in Leukocyte Interactions.- The Leukocyte-Common Antigen (L-CA) Family.- The Poly-Ig Receptor - Functional Aspects of Secretory Component Expression.- Lymphocyte Migration Molecules.- The Binding of Antigen Presenting Cells to T Lymphocytes.- B. 9th Germinal Centre Conference.- Bone Marrow, B-Cell Differentiation and the B-Cell System.- In Vivo Localization of B Lymphocyte Progenitor Cells in Mouse Bone Marrow.- Pattern of Distribution of Early B Lineage Cells in Rat Bone Marrow.- B Cell Precursor Populations in Fetal and Neonatal Rat Liver: Frequency, Topography and Antigenic Phenotype.- Rat Immununoglobulin Genes Have Comparable Patterns of JH Rearrangement in Normal Peripheral B Cells and in Pre-B and Cultured TdT+ Cells from Bone Marrow.- Chicken B Lymphocyte Differentiation: Bursal Microenvironment and Differences in Ontogeny Between Normal and SPF Birds.- Response of the Chicken Bursal Stroma to Treatment with Cyclophosphamide and IDB Virus.- Age-Dependence of Lymphocyte Production in Peyer's Follicles in Contrast to the Other Peyer's Patch Compartments and the Thymus.- Migration of Newly-Produced Virgin B Cells from Bone Marrow to Secondary Lymphoid Organs.- Memory B Cells Generated in T CellDependent Antibody Responses Colonise the Splenic Marginal Zone.- Marginal Zone B Cells and the Localisation of Antigen on Follicular Dendritic Cells.- CBA/N Mice Have Marginal Zone B Cells with Normal Surface Immunoglobulin Phenotype.- Thymus-Independent Type 2 Responses in Lymph Nodes.- Both Ly-1 B Cells and Conventional B cells Make Autoantibodies to Bromelain-Treated Autologus Erythrocytes.- IgG Subclass Distribution in Juvenile Human Tonsil: IgG3 and IgG4 Results of Specific Antibody Production Using Synthetic Peptides.- Interrelationships of Cell-Substrate and Cell-Cell Adhesion Structures in B-Chronic Lyraphocytic Leukemia (B-CLL) Cells.- Heterogeneity in the Expression of B-Cell Antigen in Non-Hodgkin's Lymphoma.- Growth Requirements of SJL Lymphomas In Vitro: Effect of BCGF II.- The Role of Follicular Dendritic Cells and Germinal Centers in Immune Reactions.- Morphological Diversity of DRC-1 Positive Cells; Human Folicular Dendritic Cells and their Relatives.- Identification of Alkaline Phosphatase Positive Cells in Human Germinal Centres as Follicular Dendritic Cells.- Isolation of Follicular Dendritic Cells From Human Tonsils and Adenoids. In Vitro Culture.- Immunohistochemical Study on Cultured FDC-C Enriched Lymphoid Cell Populations.- Interactions Between Follicular Dendritic Cells and Lymphoid Cells.- Deposits of Terminal Complement Complex and S-Protein on Follicular Dendritic Cells in Human Lymphoid Tissue.- Transport of Immune Complexes from the Subcapsular Sinus into the Lymph Node Follicles of the Rat.- FDC-Iccosome Mediated Antigen Delivery to Germinal Centre B Cells, Antigen Processing and Presentation to T Cells.- Is the Survival of Memory B Cells Dependent on the Persistence of Antigen?.- Memory B Cells but Not Virgin B Cells are Activated in Germinal Centers.- A Subpopulation of Germinal Center B Cells Differentiate Directly into Antibody Forming Cells Upon Secondary Immunization.- Specific Antibody Forming Cells in Lymphoid Follicles of Spleen: An Aspect of the Late Immune Response.- Enrichment of Germinal Centre Cells.- The Germinal Center Precursor Cell is Surface ? and ? Positive.- Surface IgD Phenotype of Rat Germinal Centre Precursor Cells.- The De Novo Generation of Germinal Centers is an Oligoclonal Process.- Changes in the Germinal Centre and Lymphocytic Corona After Peritoneal Inflammation.- Thymus, T-Cell Differentiation and the T-Cell System.- The Cholinergic and Adrenergic Innervation of the Rat Thymus.- Complex Heterogeneity of the Thymic Stroma.- Thymic Stromal Elements Defined by M. Abs: Ontogeny, and Modulation In Vivo by Immunosuppression.- Kinetics of Rat Thymic Dendritic Cells in Bone Marrow-Reconstituted Radiation Chimeras.- Allogeneic Cultured Thymic Fragments in Congenitally Athymic (Nude) Rats.- Studies on Thymic Involution: Growth Potential and DNA Repair of the Stromal Cells.- Production of Interleukin 1 (IL1) by Human Thymic Epithelial Cells (TEC).- A Low Density Fraction of Bone Marrow Cells Enriched in Prothymocyte Activity.- Kinetics of Thymocyte Regeneration in Adult Adriamycin Treated Rats: Evidence for a Bone Marrow Derived Prothymocyte Precursor.- A Study of Early Events During T Cell Differentiation in Thymic Grafted Nude Mice.- Vascular Thymustransplantation in Rats: A New Method to Study Thymocyte Kinetics.- M Receptor and Differentiation of T Lymphocytes in the Developing Human Thymus.- Homing Receptor Expression in Grafts of Purified Thymic Epithelium.- In Vitro Binding of L3T4?Lyt-2? P9P-1+ Thymocytes to Thymic Accessory Cells.- Interactions Between Lymphoid Cells and a Thymic Stromal Cell Line In Vitro.- Structural and Cellular Changes in the Mouse Thymus During Pregnancy.- Analysis of Lymphocyte Phenotype in Human Thymomas.- Thymic Hyperplasia in Myasthenia Gravis: Immunohistological Abnormalities and Responsiveness to Recombinant IL2.- Thymus Homing and Reconstitution in Split Dose Irradiated Preleukemic Mice.- Synovial T Cells Detect Polymorphism of Class II HLA Antigens.- Activated Inflammatory T Lymphocytes in Rheumatoid Synovitis - Effect of Cyclosporine A and Anti-TAC.- Inhibition of Splenic T Lymphocytes and Accessory Cell Interaction by Anti-Mac-1 (Monoclonal Antibody to Complement Receptor Type 3 ).- Mycobacterium Tuberculosis Antigen Specific Human T-Cell Lines are Cytolytic to Autologous Antigen Pulsed Macrophages.- Correlation of IL2 Production and Lymphoid Tissue Make-Up in Two Inbred Strains of Rats.- P145-MR6: A Novel T Cell Surface Molecule with a Role in Tolerance to Self.- Cell Types Involved in Non-Adaptive or Natural Immunity.- Suppression of Immunoglobulin Production by Germinal Centre HNK-1+ CD3+ Cells.- Mast Cell Response to Tumor Graft.- Interleukin-2 Induced Changes in Mononuclear Cell Surface Charge.- The Target Cells for Rat NK Cells Among Allogeneic Bone Marrow Cells.- Are Lymphokine Activated Killer Cells a Possible Form of Leukaemia Immunotherapy?.- Blood Leukocyte Natural Killer Activity as an Early Diagnostic Indicator of Leukaemic Relapse.- Proliferation of Large Granular Lymphocyte in the Rat.- Cell Traffic in the Immune System.- Establishment of Lymph Node Derived Endothelial Cell Lines which Show Lymphoid Cell Binding.- The Expression of Lymphocyte Adhesion Molecules on Cultured High Endothelial Cells.- Expression and Regulation of an Antigen Specific for Endothelium Involved in Human Lymphocyte Homing.- Changes in Lymphocyte Binding and Expression of His 22 of High Endothelial Venules in Rat Lymph Nodes After Occlusion of Afferent Lymph Flow.- Regulation of Functional and Morphological Aspects of High Endothelium in Mouse.- Substance P-Mediated Modulation of the Primary-Antibody Response.- MEL-14 and LFA-1, Organ Specific and Non-Specific Adhesion Molecules Involved in Homing of Human Lymphocytes.- Homing Receptor Expression and Migration of Activated Lymphocytes.- Reversibility of Loss of Homing Receptor Expression Following Activation.- Endocytic Stripping of Ligand from Migrant Lymphocytes in High Endothelial Venules (HEV): Implications for Immunomodulation vs viral Pathogenesis.- Xenogeneic Lymphocyte Migration in the Foetal Lamb and Unsuckled Neonatal Piglet: Evidence for the Evolutionary Conservation and Heterogeneity of Migration Determinants.- HEV Development and Trypsin-Inhibitable Localization of Lymphocytes in the Reaction to Intradermal PHA: A Receptor-Dependent Immigration and Possible Model for Peripheral CMI Reactions?.- The Migration of Lymphocyte Subsets from Blood to Lymph in the Normal rat.- The Physiological Role of the Lung in Lymphocyte Migration.- Lymphocyte Emigration from the Ovine Thymus: Characterization of Lymphatic Emigrants and Venous Emigrants.- T Lymphocyte Precursors Migrate Towards Chemotactic Peptides Secreted by Embryonic or Juvenile Thymus.- Microvasculature of the Sheep Thymus.- Tissue Localization and Migration of Murine Spleen Macrophages Carrying the Forssman Glycosphingolipid Antigen.- Migration Patterns of Dendritic Cells in the Mouse.- A Monoclonal Antibody which Reacts Specifically with a Population of Bovine Lymphocytes Lacking B Cell and T Cell Markers.- Secretory Immunity.- Meckel's Diverticle: A Gut-Associated Lymphoid Organ in Chickens.- Subpopulations of Non-Lymphoid Cells in Bronchus Associated Lymphoid Tissue and Lung of the Mouse.- Migration and Lodging of Peyer's Patch IgA Precursor Cells in the Gut Lamina Propria.- Localization, Isolation and Histochemical Characterization of Macrophages in the Gut and Mesenteric Lymph Nodes of the Rat.- Direct Transdiaphragmatic Traffic of Peritoneal Macrophages to the Lung.- Quantification and Class Distribution of Immunoglobulin-Secreting Cells in Mucosal Tissues of the Chicken.- The Identification of Murine Peyer's Patch T Cell-Derived Factors which Enhance IgA Responses.- Role of the Galt Contrasuppressor T Cell Circuit in Isotype-Specific Immunoregulation.- Evidence for Contrasuppression in Patients with Crohn's Disease.- Activated Fc Alpha T Cells in Crohn's Disease are involved in Regulation of IgA.- Induction of a Combined Mucosal and Systemic Anti-Ovalbumin Response.- Differential Expression of Epithelial MHC Class II Determinants (HLA-DR, -DP, and -DQ) and increased Class I Expression in Inflamed Salivary Glands.- Jejunal Epithelium of Patients with Coeliac Disease shows Enhanced Expression of MHC Class II Subregion Products.- T Cells and Epithelial Expression of HLA Class II Determinants in Relation to Putative M Cells of Follicle-Associated Epithelium in Human Peyer's Patches.- Modulation of Histamine Secretion from Rat and Human Mast Cell Subpopulations.- Bacterial Characteristics and Follicle Surface Structure: Their Roles in Peyer's Patch Uptake and Transport of Vibrio Cholerae.- Mucosal Priming Alters Pathogenesis of Rift Valley Fever.- J Chain is Expressed by more IgA2 than IGA1-Producing Cells in Colonie Mucosa, but it is Reduced in Both Subclasses in Inflammatory Bowel Disease.- Antigen Presentation and Cellular Interactions in Initiation and Regulation of Immune Responses.- Ontogeny of Macrophages and Dendritic Cells of the Rat.- Postnatal Development of Non-Lymphoid and Lymphoid Cell Populations In Situ in Diabetes-Prone.- Immunological Characteristics of Milky Spots in the Omentum of Rats.- Lymphoid Dendritic Cells in Rheumatoid Tissue and Normal Blood - Characteristics and Functions.- Interdigitating Cells and Dendritic Cells of the Mouse Identified by Monoclonal Antibodies. Interaction with Lymphocyte Subsets.- Phenotypic Changes in Cultured Rat Dendritic Cells: Expression of IL-2 Receptor, Thy-1 and Other Antigens.- Lymph Node Macrophage Heterogeneity: A Subpopulation Fails to Express Activation Phenotype.- Induction of the Expression of an FcR for Monometric Rat IgG2b on Rat Peritoneal Macrophages.- Activation of Mononuclear Phagocyte Functions by Structurally Different Bacterial Endotoxins.- Expression and Function of MHC Class II Antigens on Macrophages and Dendritic Cells.- Induction of Class II MHC Antigen Expression in Rat Organs After Systemic Application of Recombinant Gamma Interferon.- Human Peritoneal Macrophages Enhance HLA-DR Expression in Culture and are Very Potent Stimulators of an Allogeneic Mixed Leukocyte Reaction.- The Effects of Bacterial Lipopoly-saccharide (LPS) on High Endothelial Venules, T Lymphocytes and Interdigitating Cells in Mouse Lymph Nodes.- Intestinal Uptake of Carrageenan: Distribution and Effects on Humoral Immune Competence.- Carrageenan Induced Changes in the Immunomodulatory Capacity of Macrophages: An In Vitro Study.- Immunoregulation in Epidermis: Glucocorticoids Induced Epidermal Cell Derived Inhibitor of Interleukin 1 Activity.- Monocyte Defect Causes Decreased AutoMLR in Multiple Sclerosis Patients.- Morphological Studies on Mitogen and Antigen Presentation by Human and Rabbit Cells.- Physical Interaction Between Dendritic Cells and Lymphocytes is not LFA-1 Mediated.- The Involvement of T-cells in the Stimulatory Effect of a Water-in-Oil Emulsion on the B-Cell Response.- Impact of IgD Receptor-positive T-Cells on the Immune Response.- Spectrotype Modulation of BALB/C Anti (1-3>) Dextran 1355S Responses.- B Lymphoma Cells Process and Present Their Endogenous IG: Implications for Network Theory.- Germinal Center B Cells Present Antigen Obtained In Vivo to T Cells In Vitro and Stimulate Mixed Lymphocyte Reactions.- Characterization of Cell Populations, Reappearing in the Mouse Spleen After Elimination by Liposome Encapsuled Dichloromethylene Diphosphonate: Reappearance of Marginal Zone Lymphocytes is Independent of Marginal Zone Macrophages.- Localization of TI2 Antigen (Ficoll-FITC) and Corresponding Specific Anti-FITC Antibody Forming Cells in the Rat Spleen.- In Vitro Infection of Human Epidermal Langerhans Cell with HIV.- Accessory Cell Neoplasia as a Result of the Breakdown of Immunological Regulation?.

PRODUCT DETAILS

ISBN-13: 9781468455373
Publisher: Springer (Springer-Verlag New York Inc.)
Publication date: November, 2012
Pages: 940
Weight: 1753g
Availability: Available
Subcategories: Immunology, Physiology

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