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Clinical Epidemiology

Practice and Methods

Series: Methods in Molecular Biology

by Patrick S. Parfrey and Brendan J. Barrett

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Main description:

Focusing on improving the diagnosis, prognosis, and management of human disease, this book takes on the issues of research design, measurement, and evaluation which are critical to clinical epidemiology. This second edition of Clinical Epidemiology: Practice and Methods opens with how best to frame a clinical research question, the ethics associated with doing a research project in humans, and the definition of various biases that occur in clinical research. From there, it continues by examining issues of design, measurement, and analysis associated with various research designs, including determination of risk in longitudinal studies, assessment of therapy in randomized controlled clinical trials, and evaluation of diagnostic tests, and then delves into the more specialized area of clinical genetic research, before concluding with basic methods used in evidence-based decision making including critical appraisal, aggregation of multiple studies using meta-analysis, health technology assessment, clinical practice guidelines, development of health policy, translational research, how to utilize administrative databases, and knowledge translation. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and practical advice to ensure real world success.

Comprehensive and authoritative, Clinical Epidemiology: Practice and Methods, Second Edition is intended to educate researchers on how to undertake clinical research and should be helpful not only to medical practitioners but also to basic scientists who want to extend their work to humans, to allied health professionals interested in scientific evaluation, and to trainees in clinical epidemiology.

Contents:

Part I: Introduction

1. On Framing the Research Question and Choosing the Appropriate Research Design

Patrick S. Parfrey and Pietro Ravani

2. Research Ethics for Clinical Researchers

John D. Harnett and Richard Neuman

3. Definitions of Bias in Clinical Research

Geoffrey Warden

Part II: Longitudinal Studies

4. Longitudinal Studies 1: Determination of Risk

Sean W. Murphy

5. Longitudinal Studies 2: Modeling Data Using Multivariate Analysis

Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey

6. Longitudinal Studies 3: Data Modeling Using Standard Regression Models and Extensions

Pietro Ravani, Brendan J. Barrett, and Patrick S. Parfrey

7. Longitudinal Studies 4: Matching Strategies to Evaluate Risk

Matthew T. James

8. Longitudinal Studies 5: Development of Risk Prediction Models for Patients with Chronic Disease

Navdeep Tangri and Claudio Rigatto

Part III: Randomized Controlled Clinical Trials

9. Randomized Controlled Trials 1: Design

Bryan M. Curtis, Brendan J. Barrett, and Patrick S. Parfrey

10. Randomized Controlled Trials 2: Analysis

Robert N. Foley

11. Randomized Controlled Trials 3: Measurement and Analysis of Patient-Reported Outcomes

Michelle M. Richardson, Megan E. Grobert, and Klemens B. Meyer

12. Randomized Controlled Trials 4: Biomarkers and Surrogate Outcomes

Claudio Rigatto and Brendan J. Barrett

13. Randomized Controlled Trials 5: Determining the Sample Size and Power for Clinical Trials and Cohort Studies

Tom Greene

14. Randomized Controlled Trials 6: On Contamination and Estimating the Actual Treatment Effect

Patrick S. Parfrey

15. Randomized Controlled Trials 7: Analysis and Interpretation of Quality of Life Scores

Robert N. Foley and Patrick S. Parfrey

16. Randomized Controlled Trials 8: Planning, Monitoring, and Execution

Elizabeth Hatfield, Elizabeth Dicks, and Patrick S. Parfrey

Part IV: The Basics for Other Clinical Epidemiology Methods

17. Evaluation of Diagnostic Tests

John M. Fardy and Brendan J. Barrett

18. Qualitative Research in Clinical Epidemiology

Deborah M. Gregory and Christine Y. Way

19. Health Economics in Clinical Research

Braden J. Manns

Part V: Clinical Genetic Research

20. Clinical Genetic Research 1: Bias

Susan Stuckless and Patrick S. Parfrey

21. Clinical Genetic Research 2: Genetic Epidemiology of Complex Phenotypes

Darren D. O'Rielly and Proton Rahman

22. Clinical Genetic Research 3: Genetics ELSI (Ethical, Legal and Social Issues) Research

Daryl Pullman and Holly Etchegary

Part VI: Methods in Evidence-Based Decision Making

23. Evidence-Based Decision Making 1: Critical Appraisal

Laurie K. Twells

24. Evidence-Based Decision Making 2: Systematic Reviews and Meta-Analysis

Aminu Bello, Natasha Wiebe, Amit Garg, and Marcello Tonelli

25. Evidence-Based Decision Making 3: Health Technology Assessment

Daria O'Reilly, Kaitryn Campbell, Meredith Vanstone, James M. Bowen, Lisa Schwartz, Nazila Assasi, and Ron Goeree

26. Evidence-Based Decision Making 4: Development and Limitations of Clinical Practice Guidelines

Bruce Culleton

27. Evidence-Based Decision-Making 5: Translational Research

Deborah M. Gregory and Laurie K. Twells

28. Evidence-Based Decision Making 6: Utilization of Administrative Databases for Health Services Research

Turin Chowdury and Brenda Hemmelgarn

29. Evidence-Based Decision Making 7: Knowledge Translation

Braden J. Manns

30. Evidence-Based Decision Making 8: Health Policy, A Primer for Researchers

Victor Maddalena

PRODUCT DETAILS

ISBN-13: 9781493924271
Publisher: Springer (Humana Press Inc.)
Publication date: February, 2015
Pages: 520
Weight: 652g
Availability: Available
Subcategories: Epidemiology, General Issues

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