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Main description:
This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results.
Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.
Contents:
Part I: Background: Epigenetic Mechanism
1. Cancer Epigenetics: An Introduction
Rajnee Kanwal, Karishma Gupta, and Sanjay Gupta
2. Community Resources and Technologies Developed Through the NIH Roadmap Epigenomics Program
John S. Satterlee, Andrea Beckel-Mitchener, Kim McAllister, Dena C. Procaccini, Joni L. Rutter, Frederick L. Tyson, and Lisa Helbling Chadwick
3. Epigenome-Wide Association Studies (EWAS): Past, Present, and Future
James M. Flanagan
4. Epigenetic Biomarkers in Liver Cancer
Krishna K. Banaudha and Mukesh Verma
Part II: Cancer Specific Type Epigenetic Changes
5. Cancer Type Specific Epigenetic Changes: Gastric Cancer
Danielle Queiroz Calcagno, Marilia de Arruda Cardoso Smith, and Rommel Rodriguez Burbano
6. Beyond the Island: Epigenetic Biomarkers of Colorectal and Prostate Cancer
Andrea J. Savio and Bharati Bapat
7. Prostate Cancer Epigenome
Swathi Chinaranagari, Pankaj Sharma, Nathan J. Bowen, and Jaideep Chaudhary
8. CpG Island Hypermethylation as a Biomarker for the Early Detection of Lung Cancer
Yujin Kim and Duk-Hwan Kim
9. Analysis of DNA Methylation in Pancreatic Cancer: An Update
Christian Pilarsky and Robert Grutzmann
10. Epigenetics of Urothelial Carcinoma
Wolfgang A. Schulz, Evangelia A. Koutsogiannouli, Gunter Niegisch, and Michele J. Hoffmann
11. Epigenetics of Prostate Cancer
Tawnya C. McKee and James V. Tricoli
12. Methylation Profile Landscape in Mesothelioma: Possible Implications in Early Detection, Disease Progression, and Therapeutic Options
Xinbo Zhang, Naimei Tang, Arun K. Rishi, Harvey I. Pass, and Anil Wali
Part III: Methods and Technologies Used for Detecting Epigenetic Changes
13. Techniques to Access Histone Modifications and Variants in Cancer
Monica Tyagi, Shafqat A Khan, Saikat Bhattacharya, Divya Reddy, Ajit K Sharma, Bharat Khade, and Sanjay Gupta
14. Single Base Resolution Analysis of 5-Methylcytosine and 5-Hydroxymethylcytosine by RRBS and TAB-RRBS
Maria A. Hahn, Arthur X. Li, Xiwei Wu, and Gerd P. Pfeifer
15. Quantitative DNA Methylation Analysis for Epigenotyping of Colorectal Cancer
Atsushi Kaneda and Koichi Yagi
16. Histone Modifications Associated with Cancer Cell Migration and Invasion
Miki Hieda, Nariaki Matsuura, and Hiroshi Kimura
Part IV: Factors that Influence Epigenetic Changes in Cancer
17. Aberrant Epigenetic Modifications in Radiation-Resistant Head and Neck Cancers
Hon-Yi Lin, Tim Hui-Ming Huang, and Michael Wing-Yan Chan
18. Cancer-Associated Infectious Agents and Epigenetic Regulation
Vidya Vedham and Mukesh Verma
19. Toxicoepigenomics and Cancer: Implications for Screening
Mukesh Verma
20. Human Papilloma Virus (HPV) Modulation of the HNSCC Epigenome
Josena K. Stephen and Maria J. Worsham
21. Epigenetic Regulation of HIV, AIDS, and AIDS-Related Malignancies
Mukesh Verma
22. Epigenetics of Colorectal Cancer
Wenji Yan and Mingzhou Guo
23. Epigenetics in Breast and Prostate Cancer
Yanyuan Wu, Marianna Sarkissyan, and Jaydutt V. Vadgama
Part V: Future Directions: Risk Assessment, Diagnosis, Treatment, and Prognosis
24. Epigenetic Inhibitors
Mukesh Verma and Hirendra Nath Banerjee
25. Use of Epigenetic Modulators as a Powerful Adjuvant for Breast Cancer Therapies
Aurore Claude-Taupin, Michael Boyer-Guittaut, Regis Delage-Mourroux, and Eric Hervouet
26. Epigenetic Approaches in Glioblastoma Multiforme and Their Implication in Screening and Diagnosis
Gwyneth Hyman, Vinod Manglik, Jeffrey M. Rousch, Mukesh Verma, David Kinkebiel, and Hirendra Nath Banerjee
27. Detection of Circulatory MicroRNAs in Prostate Cancer
Anvesha Srivastava, Helle Goldberger, Zainab Afzal, Simeng Suy, Sean P. Collins, and Deepak Kumar
28. Identification and Characterization of Small-Molecule Inhibitors of Lysine Acetyltransferases
Daiqing Liao
29. Epigenetic Regulation in Biopsychosocial Pathways
Kristin Litzelman and Mukesh Verma
30. Viral Epigenetics
Barry I. Milavetz and Lata Balakrishnan
31. P53 Tumor Suppression Network in Cancer Epigenetics
Alok Mishra, Daniel J. Brat, and Mukesh Verma
32. Promoter Hypermethylation as a Biomarker in Prostate Adenocarcinoma
Jong Y. Park
33. Sequencing the Cancer Methylome
Austin Y. Shull, Satish K. Noonepalle, Eun-Joon Lee, Justin Choi, and Huidong Shi
34. Global DNA Methylation Profiling Technologies and the Ovarian Cancer Methylome
Jessica Tang, Fang Fang, Dave F. Miller, Jay M. Pilrose, Daniela Matei, Tim H.-M. Huang, and Kenneth P. Nephew
35. Recent Progress in the Discovery of Epigenetic Inhibitors for the Treatment of Cancer
Sharad K. Verma
36. At the Crossroad Between Obesity and Gastric Cancer
Robert B. Uddo, Jone Garai, Maura C. Mohler, Nicole Pelligrino, Richard Scribner, Melinda S. Sothern, and Jovanny Zabaleta
37. Detection of Epigenetic Aberrations in the Development of Hepatocellular Carcinoma
Yujing Zhang
38. Specific Type Epigenetic Changes in Cervical Cancers
Shuping Zhao
39. Epigenetics in Head and Neck Cancer
Syeda Marriam Bakhtiar, Amjad Ali, and Debmalya Barh
40. Epigenetic Therapy for Colorectal Cancer
Vivek Vaish, Tripti Khare, Mukesh Verma, and Sharad Khare
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2014
Pages: 830
Weight: 652g
Availability: Available
Subcategories: Genetics, Oncology
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