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Main description:
As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.
Contents:
1. Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains
Michael F.W. Festing
2. The Sophisticated Mouse: Protecting a Precious Reagent
Michael V. Wiles and Rob A. Taft
3. Genetically Engineered Mouse Models in Drug Discovery Research
Rosalba Sacca, Sandra J. Engle, Wenning Qin, Jeffrey L. Stock, and John D. McNeish
4. Engineering the Mouse Genome to Model Human Disease for Drug Discovery
Frank Koentgen, Gabriele Suess, and Dieter Naf
5. Profiling of Drug Action Using Reporter Mice and Molecular Imaging
Gianpaolo Rando, Andrea Biserni, Paolo Ciana, and Adriana Maggi
6. Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies
Derry C. Roopenian, Gregory J. Christianson, and Thomas J. Sproule
7. Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease
Steve Pino, Michael A. Brehm, Laurence Covassin-Barberis, Marie King, Thomas H. Chase, Jennifer Wagner, Lisa Burzenski, Oded Foreman, Dale L. Greiner, and Leonard D. Shultz
8. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans
David V. Serreze, Marijke Niens, John Kulik, and Teresa P. DiLorenzo
9. Mouse Models of Type II Diabetes Mellitus in Drug Discovery
Helene Baribault
10. Cholesterol Absorption and Metabolism
Philip N. Howles
11. Collagen-Induced Arthritis in Mice
Lisette Bevaart, Margriet J. Vervoordeldonk, and Paul-Peter Tak
12. Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening
John P. Sundberg, Kathleen A. Silva, Caroline McPhee, and Lloyd E. King, Jr. Characterization and Treatment of Epidermolysis Bullosa
Jason A. Bubier, Thomas J. Sproule, John P. Sundberg, and Derry C. Roopenian
14. Models of Metastasis in Drug Discovery
James E. Talmadge
15. Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/ Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging
David Surguladze, Philipp Steiner, Marie Prewett, and James R. Tonra
16. CML Mouse Model in Translational Research
Cong Peng and Shaoguang Li
17. Mouse Models for Studying Depression-Like States and Antidepressant Drugs
Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, and Allan V. Kalueff
18. Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors
Amy W. Lasek and Nourredine Azouaou
19. Experimental Models of Anxiety for Drug Discovery and Brain Research
Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte, and Allan V. Kalueff
20. Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology
Christopher Janus and Hans Welzl
21. Neuromuscular Disease Models and Analysis
Robert W. Burgess, Gregory A. Cox, and Kevin L. Seburn
22. Murine Model of Pneumococcal Pneumonia
Eva Medina
23. Murine Model of Cutaneous Infection with Streptococcus pyogenes
Eva Medina
24. Murine Model of Polymicrobial Septic Peritonitis Using Cecal Ligation and Puncture (CLP)
Eva Medina
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2009
Pages: 433
Weight: 1111g
Availability: Available
Subcategories: General Issues, Pharmacology
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