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Main description:
The epigenetic regulation plays an important role in normal development and maintenance of tissue specific genes expression in humans and the disturbance of these patterns lead to changes involved in tumor formation. More recently, epigenetic changes have been observed in early stages of tumor development and together with the genetic alterations have been defined as abnormalities, necessary for cancer initiation and progression. In, Cancer Epigenetics: Methods and Protocols, expert researchers reviewed these epigenetics changes in different tumor types and described several technologies that are currently available to detect epigenetic changes. These technologies have lead to a better understanding of the processes in normal and cancerous cells. Written in the highly successful Methods in Molecular Biology (TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Thorough and intuitive, Cancer Epigenetics: Methods and Protocols aids scientists in continuing to study epigenetic alterations used in clinical practice as biomarkers of early cancerous lesions or markers of progression and prognosis.
Contents:
Part I: Early Epigenetic Events in Cancer
1. Epigenetic Markers of Early Tumor Development
Ramona G. Dumitrescu
2. Epigenetics of Solid Cancer Stem Cells
Alok Mishra and Mukesh Verma
Part II: Cancer Specific Type Epigenetic Changes
3. DNA Methylation and Histone Modifications in Breast Cancer
Ramona G. Dumitrescu
4. DNA Methylation Changes in Prostate Cancer
Wolfgang Goering, Michael Kloth, Wolfgang A. Schulz
5. DNA Methylation in Promoter Region as Biomarkers in Prostate Cancer
Mihi Yang and Jong Y. Park
6. Epigenetics of Bladder Cancer
Wun-Jae Kim and Yong-June Kim
7. Epigenetics in Myeloid Malignancies
Stefan Deneberg
8. The Epigenetics of Brain Tumors
Adrian M. Dubuc, Stephen Mack, Alexander Unterberger, Paul A. Northcott and Michael D. Taylor
9. DNA Methylation Changes in Cervical Cancers
Qiang Lu, Dehua Ma, Shuping Zhao
10. Epigenetics of Colon Cancer
Sharad Khare and Mukesh Verma
11. Promoter Methylation in Head and Neck Tumorigenesis
Josena K. Stephen, Kang Mei Chen, Shaleta Havard, Glynis Harris, Maria J. Worsham
12. Epigenome and DNA Methylation in Oral Squamous Cell Carcinoma
Mario Perez-Sayans Garcia and Abel Garcia-Garcia
13. Clinical Implications of Epigenetic Alterations in Human Thoracic Malignancies: Epigenetic Alterations in Lung Cancer
Keiko Shinjo and Yutaka Kondo
14. The Role of microRNAs in the Management of Liver Cancer
Krishna K Banaudha and Mukesh Verma
15. Epigenetics in Ovarian Cancer
L.M.S. Seeber, P.J. van Diest
Part III: Methods and Technologies used for Epigenetic Changes Detection
16. DNA Methylation in Pancreatic Cancer: Protocols for the Isolation of DNA and Bisulfite Modification
Katja Biewusch, Marie Heyne, Robert Grutzmann, Christian Pilarsky
17.Detection and Analysis of DNA Methylation by Pyrosequencing
Hilary A. A. Colyer, Richard N. Armstrong, Dr. Daniel J. Sharpe and Ken I. Mills
18. Screening for miRNA Experssion Changes using Quantitative PCR (Q-PCR)
Richard N. Armstrong, Hilary A. A. Colyer, Ken. I. Mills
19. Genome-wide Methylation Analysis
Alexander Unterberger, Adrian M. Dubuc and Michael D. Taylor
20. Microarray for Epigenetic Changes: Gene Expression Arrays
Hilary A. A. Colyer, Richard N. Armstrong and Ken I. Mills
21. Detecting DNA Methylation using the Methylated CpG Island Amplification and Microarray Technique
Hiliary A. A. Colyer, Margaret Dellett and Ken I. Mills
Part IV. Factors that Influence the Epigenetic Changes in Cancer
22. Nutrigenomics-Implications for Breast and Colon Cancer Prevention
Gabriela Riscuta and Ramona G. Dumitrescu
23. Dietary and Lifestyle Factors of DNA Methylation
Unhee Lim and Min-Ae Song
24. Diet, Epigenetics and Cancer
Joseph L. Su
25. Role of Epigenetics in Cancer Health Disparities
Sulma I. Mohammed, Sanya Springfield, and Rina Das
26. Multifactorial Etiology of Gastric Cancer
Rosa A. Sierra, Jovanny Zabaleta
Part V. Epigenetic Epidemiology
27. Epigenetic Epidemiology for Cancer Risk: Harnessing Germline Epigenetic Variation
Kevin Brennan and James M. Flanagan
28. Epigenetic Biomarkers in Cancer Epidemiology
Mukesh Verma
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: February, 2012
Pages: 505
Weight: 1143g
Availability: Available
Subcategories: Genetics, Oncology
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