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Psychiatric Disorders

Methods and Protocols

Series: Methods in Molecular Biology

by Firas H. Kobeissy and Firas Kobeissy

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Main description:

New high throughput techniques in neuroscience and psychiatry have enhanced the development of experimental, customizable animal models that are predictive of human neuropsychiatric pathology and give vital insights on the mechanisms and pathways involved. In Psychiatric Disorders: Methods and Protocols, key experts have written integrated chapters on neuropsychiatric research sharing their insightful expertise and opinions focusing on both the animal models as well as the cutting edge techniques applied. Beginning with an overview of the animal research in psychiatric illness and substance abuse, this comprehensive volume continues with the modeling of neuropsychiatric illness, drug abuse paradigms and techniques, biomarker identification, autoimmune inflammatory response, and neuroendocrine alteration in the areas of psychiatry, as well as state-of-the-art "Omics approaches" and neurosystems biology/data mining techniques to compute and analyze genomic and proteomics alteration occurring within neuropsychiatric models. As a part of the highly successful Methods in Molecular Biology (TM) series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Thorough and easily applicable, Psychiatric Disorders: Methods and Protocols offers the detailed and clearly illustrated tools necessary for neuroscientists and psychiatrists to handle many unanswered scientific questions with a more creative and insightful approach.

Contents:

Part I: Overview of the Animal Research in Psychiatric Illness and Substance Abuse

1. New Frontiers in Animal Research of Psychiatric Illness

Arie Kaffman and John J. Krystal

2. Experimental Psychiatric Illness and Drug Abuse Models: From Human to Animal, An Overview

Scott Edwards and George F. Koob

3. Qualitative Vs. Quantitative Methods in Psychiatric Research

Mahdi Razafsha, Hura Behforuzi, Hassan Azari, Zhiqun Zhang,Kevin K. Wang, Firas H. Kobeissy, and Mark S. Gold

Part II: Methods in Animal Models of Psychiatric Illness

4. Animal Models of Self-Injurious Behavior: An Overview

Darragh P. Devine

5. Rodent Models of Adaptive Decision Making

Alicia Izquierdo and Annabelle M. Belcher

6. Animal Models of Depression and Neuroplasticity: Assessing Drug Action in Relation to Behavior and Neurogenesis

Ying Xu, Philip A. Barish, Jianchun Pan, William O. Ogle, and James M. O'Donnell

7. Modeling Depression in Animal Models

David H. Overstreet

8. Behavioral Model for Assessing Cognitive Decline

Michael Guidi and Thomas C. Foster

9. The Pemoline Model of Self-Injurious Behavior

Darragh P. Devine

10. Modeling Risky Decision Making in Rodents

Nicholas W. Simon and Barry Setlow

11. Modeling Open Space Anxiety Test in Rodents: The Elevated Platform with Steep Slopes

Abdelkader Ennaceur

12. An Animal Model to Study the Molecular Basis of Tardive Dyskinesia

Mahendra Bishnoi and Ravneet K. Boparai

Part III: Methods in Animal Models of Substance Abuse

13. Models of Chronic Alcohol Exposure and Dependence

Darin J. Knapp and George R. Breese

14. Rat Models of Prenatal and Adolescent Cannabis Exposure

Jennifer A. DiNieri and Yasmin L. Hurd

15. Modeling Nicotine Addiction in Rats

Stephanie Caille, Kelly Clemens, Luis Stinus, and Martine Cador

16. Animal Models of Nicotine Withdrawal: Intracranial Self-Stimulation and Somatic Signs of Withdrawal

Rayna M. Bauzo and Adrie W. Bruijnzeel

17. Methods in Drug Abuse Models: Comparison of Different Models of Methamphetamine Paradigms

Firas H. Kobeissy, Jeremiah D. Mitzelfelt, Irina Fishman, Drake Morgan, Roger Gaskins, Zhiqun Zhang, Mark S Gold, and Kevin Wang

18. Cocaine Self-Administration in Rats: Hold Down Procedures

Benjamin A. Zimmer and David C.S. Roberts

19. Cocaine Self-Administration in Rats: Discrete Trials Procedures

Carson V. Dobrin and David C.S. Roberts

20. Cocaine Self-Administration in Rats: Threshold Procedures

Erik B. Oleson and David C.S. Roberts

21. Assessing Locomotor-Stimulating Effects of Cocaine in Rodents

Drake Morgan, Jameson P. DuPree, Alex D. Bibbey, and Glen M. Sizemore

22. Methods in Tobacco Abuse: Proteomic Changes Following Second-Hand Smoke Exposure

Joy Guingab-Cagmat, Rayna M. Bauzo, Adrie W. Bruijnzeel, Kevin Wang, Mark S. Gold, and Firas H. Kobeissy

Part IV: Methods in Animal Models of Eating Disorders

23. Animal Models of Sugar and Fat Bingeing: Relationship to Food Addiction and Increased Body Weight

Nicole M. Avena, Miriam E. Bocarsly, and Bartley G. Hoebel

24. Animal Models of Overeating

Neil E. Rowland

25. The Activity-Based Anorexia Mouse Model

Stephanie J. Klenotich and Stephanie C. Dulawa

Part V: Biomarkers, Neuroendocrine and Inflammatory Profiles Relevant to Neuropsychiatric Disorders

26. Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models

Amy S. Kohtz and Cheryl A. Frye

27. Interleukin-2 and the Septohippocampal System: Intrinsic Actions and Autoimmune Processes Relevant to Neuropsychiatric Disorders

John M. Petitto, Zhi Huang, Danielle Meola, Grace K. Ha, and Daniel Dauer

28. Experimental Schizophrenia Models in Rodents Established with Inflammatory Agents and Cytokines

Hiroyuki Nawa and Kiyofumi Yamada

29. P11: A Potential Biomarker for Posttraumatic Stress Disorder (PTSD)

Lei Zhang and He Li

Part VI: "Omics" Analysis and Systems Biology Applications in Psychiatric Disorders

30. Investigation of Age-Specific Behavioral and Proteomic Changes in an Animal Model of Chronic Ethanol Exposure

Antoniette M. Maldonado-Devincci, Stanley M. Stevens, Jr., and Cheryl L. Kirstein

31. Quantitative Peptidomics to Measure Neuropeptide Levels in Animal Models Relevant to Psychiatric Disorders

Julia S. Gelman, Jonathan Wardman, Vadiraja B. Bhat, Fabio C. Gozzo, and Lloyd D. Fricker

32. ADHD Animal Model Characterization: Transcriptomics and Proteomics Analyses

Yoshinori Masuo, Junko Shibato, and Randeep Rakwal

33. Psychiatric Disorder Biomarker Discovery Using Quantitative Proteomics

Michaela D. Filiou and Christoph W. Turck

34. Gene Profiling of Laser-Microdissected Brain Regions and Individual Cells in Drug Abuse and Schizophrenia Research

Pietro Paolo Sanna, Vez Repunte-Canonigo, and Alessandro Guidotti

35. Stable Isotope Labeling with Amino Acids in Cell Culture (SILAC)-Based Proteomic Analysis of Ethanol-Induced Protein Expression Profiles in Microglia

Bin Liu, David S. Barber, and Stanley M. Stevens, Jr.

36. Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations

Felix Tretter and Peter J. Gebicke-Haerter

37. Data Mining in Psychiatric Research

Diego Tovar, Eduardo Cornejo, Petros Xanthopoulos, Mario R. Guarracino, and Panos M. Pardalos

PRODUCT DETAILS

ISBN-13: 9781617794575
Publisher: Springer (Humana Press Inc.)
Publication date: January, 2012
Pages: 636
Weight: 1369g
Availability: Available
Subcategories: Neuroscience, Psychiatry

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