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Pharmacogenomics in Drug Discovery and Development

Series: Methods in Molecular Biology

by Qing Yan

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Pharmacogenomics in Drug Discovery and Development

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Main description:

The field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In this book, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. The volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. This book is ideal for scientists striving to transform disease treatment into disease prevention.

Contents:

Table of Contents 1. The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery Qing Yan 2. Applications of Microarrays and Biochips in Pharmacogenomics Gary Hardiman 3. Confounding in Genetic Association Studies and Its Solutions Donglei Hu and Elad Ziv 4. Pharmacogenetics of Membrane Transporters: A Review of Current Approaches Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg 5. Pharmacogenomics of Drug Metabolizing Enzymes and Drug Transporters in Chemotherapy Tessa M. Bosch 6. Pharmacogenomics of G Protein-coupled Receptor Signaling: Insights from Health and Disease Miles D. Thompson, David E.C. Cole and Pedro A. Jose 7. G Protein-coupled Receptors Disrupted in Human Genetic Disease Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, and David E.C. Cole 8. G Protein-coupled Receptor Pharmacogenetics Miles D. Thompson, Katherine A. Siminoivitch, and David E.C. Cole 9. Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders Hamid Mostafavi Abdolmaleky and Sam Thiagalingam 10. Pharmacogenomics in Alzheimer's Disease Ramon Cacabelos 11. Pharmacogenetics of Asthma Gregory A. Hawkins and Stephen P. Peters 12. From SNPs to Functional Studies in Cardiovascular Pharmacogenomics Sharon Cresci 13. Pharmacogenomics in Gastrointestinal Disorders Michael Camilleri and Yuri A. Saito 14. Pharmacogenomics in Rheumatoid Arthritis Prabha Ranganathan 15. Cancer Pharmacogenetics Sharon Marsh 16. Pharmacogenomics in the Preclinical Development ofVaccines: Evaluation of Efficacy and Systemic Toxicity in Mouse Using Array Technology Karin J. Regnstroem 17.Pharmacogenomics in the Evaluation of Efficacy and Adverse Events during Clinical Development of Vaccines Lennart J. Nilsson and Karin J. Regnstroem

PRODUCT DETAILS

ISBN-13: 9781617378256
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 500
Weight: 765g
Availability: Available
Subcategories: Biochemistry, Genetics, Pharmacology

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