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Tumor Suppressor Genes

Volume 2: Regulation, Function, and Medicinal Applications

Series: Methods in Molecular Biology

by Wafik S. El-Deiry

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Main description:

It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.

Contents:

Part I. Understanding the Function and Regulation of Tumor Suppressor Genes

Utilizing NMR to Study the Structure of Growth-Inhibitory Proteins
Francesca M. Marassi

Generation and Application of Phospho-Specific Antibodies for p53 and pRB
Yoichi Taya, Kiichiro Nakajima, Kumiko Yoshizawa-Kumagaye, and Katsuyuki Tamai

Stability and Ubiquitination of the Tumor Suppressor Protein p53
Lesley J. Jardine and Carl G. Maki

Role of Tumor Suppressors in DNA Damage Response
Bin-Bing S. Zhou, Michael R. Mattern, and Kum Kum Khanna

In Situ Hybridization in Cancer and Normal Tissue
Shrihari Kadkol, Jeremy Juang, and Tzyy-choou Wu

Genetic Strategies in Saccharomyces cerevisiae to Study Human Tumor Suppressor Genes
Takahiko Kobayashi, Ting Wang, Hua Qian, and Rainer K. Brachmann

Electrophoretic Mobility Shift Analysis of the DNA Binding of Tumor Suppressor Gene Products
Edward C. Thornborrow, Matthew Maurer, and James J. Manfredi

Analysis of Gene Promoter Regulation by Tumor Suppressor Genes
Kumaravel Somasundaram, Sanjeev Das, Smita Lakhotia, and Narendra Wajapeyee

DNA Footprinting
M. Stacey Ricci and Wafik S. El-Deiry

Identification of DNA-Binding of Tumor Suppressor Genes by Chromatin Immunoprecipitation
Timothy K. MacLachlan and Wafik S. El-Deiry

Co-immunoprecipitation of Tumor Suppressor Protein-Interacting Proteins
Li-Kuo Su

Microarray Approaches for Analysis of Tumor Suppressor Gene Function
Sally A. Amundson and Albert J. Fornace, Jr.

Analysis of Tumor Suppressor Gene-Induced Senescence
Judith Campisi

Yeast Two-Hybrid Screening as a Means of Deciphering Tumor Suppressor Pathways
E. Robert McDonald III and Wafik S. El-Deiry

Somatic Cell Knockouts of Tumor Suppressor Genes
Ruth Hemmer, Wenyi Wei, Annie Dutriaux, and John M. Sedivy

Colony Growth Suppression by Tumor Suppressor Genes
Gen Sheng Wu

Flow Cytometric Analysis of Cell Cycle Control by Tumor Suppressor Genes
David T. Dicker and Wafik S. El-Deiry

Analysis of Cyclin-Dependent Kinase Activity
Timothy K. MacLachlan and Wafik S. El-Deiry

Tumor Suppressor Gene-Inducible Cell Lines
Michael Dohn, Susan Nozell, Amy Willis, and Xinbin Chen

In Vitro Models of Early Neoplastic Transformation of Human Mammary Epithelial Cells
Vimla Band

Tumor Suppression Through Angiogenesis Inhibition
Andrew M. Arsham and M. Celeste Simon

Flow Cytometric Analysis of Tumor Suppressor Gene-Induced Apoptosis
David T. Dicker and Wafik S. El-Deiry

Functional Analysis of Tumor Suppressor Genes in Mice
Stephen N. Jones and Lawrence A. Donehower

The Tissue Microenvironment as an Epigenetic Tumor Modifier
Meredith Unger and Valerie M. Weaver

Analyzing the Function of Tumor Suppressor Genes Using a Drosophila Model
Raymond A. Pagliarini, Ana T. Quinones, and Tian Xu

Assembling a Tumor Progression Model
Mark Redston

Conformation-Sensitive Gel Electrophoresis for Detecting BRCA1 Mutations
Smita Lakhotia and Kumaravel Somasundaram

Part II. Medicinal Applications of Tumor Suppressors

Conversion Technology and Cancer Predispositions
Nickolas Papadopoulos

Discovering Novel Anticancer Drugs: Practical Aspects and Recent Advances
Cristina T. Lewis and Patrick M. O'Connor

Targets in Apoptosis Signaling: Promise of Selective Anticancer Therapy
Ramadevi Nimmanapalli and Kapil Bhalla

Tumor Deprivation of Oxygen and Tumor Suppressor Gene Function
Zhong Yun and Amato J. Giaccia

Hormonal and Differentiation Agents in Cancer Growth Suppression
Mikhail V. Blagosklonny

Regulation of NF-kB by Oncoproteins and

PRODUCT DETAILS

ISBN-13: 9781489939142
Publisher: Springer (Humana Press Inc.)
Publication date: October, 2013
Pages: 657
Weight: 1274g
Availability: Available
Subcategories: Oncology

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