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Main description:
Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter's words in 1795, "inflammation is a salutary response." That may be applied in particular to the defensive response to invading micro- ganisms.
Contents:
Part I. In Vitro Systems for Studying Aspects of the Inflammatory Response and Testing Antiinflammatory Drugs
Key Stages in the Acute Inflammatory Response and Their Relevance as Therapeutic Targets: Introduction to Part 1
Paul G. Winyard
IkB Kinase and NF-kB Signaling in Response to Pro-Inflammatory Cytokines
Mireille Delhase
Screening for Inhibitors of Transcription Factors, Using Luciferase Reporter Gene Expression in Transfected Cells
Deborah Phippard and Anthony M. Manning
Adhesion Molecule Expression on Cytokine-Stimulated Human Endothelial Cells
Susan L. Cuvelier and Kamala D. Patel
Phagocytosis by Inflammatory Phagocytes: Experimental Strategies for Stimulation and Quantification
M. Rachel Morris, Sharon Dewitt, Iraj Laffafian, and Maurice B. Hallett
Cytosolic Ca2+ Measurement and Imaging in Inflammatory Cells
Sharon Dewitt, Iraj Laffafian, M. Rachel Morris, and Maurice B. Hallett
Detection and Visualization of Oxidase Activity in Phagocytes
Maurice B. Hallett, Caroline Cole, and Sharon Dewitt
Measurement of Complement Activation
Tom Eirik Mollnes
Measurement of Matrix Metalloproteinase Activities in the Medium of Cultured Synoviocytes Using Zymography
Linda Troeberg and Hideaki Nagase
Measurement of Aggrecanase-Generated Interglobular Domain Catabolites in the Medium and Extracts of Cartilage Explants Using Western Blot Analysis
Clare E. Hughes, Christopher B. Little, and Bruce Caterson
In Vitro Model of Human Articular Cartilage Degradation
William D. Shingleton
Part II. In Vivo Models of Inflammation
In Vivo Models of Inflammation: Introduction to Part 2
Derek A. Willoughby
Carrageenan-Induced Paw Edema in the Rat and Mouse
Christopher J. Morris
Pleural Models of Inflammation: Immune and Nonimmune
Adrian R. Moore
Models of Acute Inflammation in the Ear
Miklos Gabor
Migration of Specific Leukocyte Subsets in Response to Cytokine or Chemokine Application In Vivo
Mauro Perretti and Stephen J. Getting
Inflammatory Joint Disease: Clinical, Histological, and Molecular Parameters of Acute and Chronic Inflammation and Tissue Destruction
Nancy L. McCartney-Francis, James Chan, and Sharon M. Wahl
The Assessment of Inflammation, Cartilage Matrix, and Bone Loss in Experimental Monoarticular Arthritis of the Rat
Michael P. Seed
Collagen-Induced Arthritis
Adrian R. Moore
Air-Pouch Models of Inflammation and Modifications for the Study of Granuloma-Mediated Cartilage Degradation
Paul Colville-Nash and Toby Lawrence
Quantitative Analysis of Angiogenesis Using the Murine Chronic Granulomatous Air Pouch
Chandan A. S. Alam
Models of Coronary Artery Occlusion and Reperfusion for the Discovery of Novel Antiischemic and Antiinflammatory Drugs for the Heart
Nicole S. Wayman, Michelle C. McDonald, Prabal K. Chatterjee, and Christoph Thiemermann
Assessment of Anticolitic Drugs in the Trinitrobenzene Sulfonic Acid (TNBS) Rat Model of Inflammatory Bowel Disease
Brendan J. R. Whittle, Maryan Cavicchi, and Dominique Lamarque
An In Vivo Model of Ischemia/Reperfusion and Inflammation of the Kidneys of the Rat
Prabal K. Chatterjee and Christoph Thiemermann
In Vivo Models of Inflammation: Immune Rejection and Skin Transplantation In Vivo
Isabelle Binet and Kathryn J. Wood
Wound Healing: A Model of Dermal Wound Repair
Annette Tomlinson and Mark W. J. Ferguson
Part III. Pharmacodynamic Endpoints in Experimental Models and in Clinical Studies in Humans
An Iconoclastic Approach to Pharmacodynamics in Model Systems: Their Relevance to Humans: Introduction to Part 3
David R. Blake and Gordon J.
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: November, 2010
Pages: 390
Weight: 664g
Availability: Available
Subcategories: Immunology
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