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Liposomes
Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers
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Main description:

Efforts to describe and model the molecular structure of biological membranes go back to the beginning of the last century. In 1917, Langmuir described membranes as a layer of lipids one molecule thick [1]. Eight years later, Gorter and Grendel concluded from their studies that "the phospholipid molecules that formed the cell membrane were arranged in two layers to form a lipid bilayer" [2]. Danielli and Robertson proposed, in 1935, a model in which the bilayer of lipids is sequestered between two monolayers of unfolded proteins [3], and the currently still accepted fuid mosaic model was proposed by Singer and Nicolson in 1972 [4]. Among those landmarks of biomembrane history, a serendipitous observation made by Alex Bangham during the early 1960s deserves undoubtedly a special place. His fnding that exposure of dry phospholipids to an excess of water gives rise to lamellar structures [5] has opened versatile experimental access to studying the biophysics and biochemistry of biological phospholipid membranes. Although during the following 4 decades biological membrane models have grown in complexity and functionality [6], liposomes are, besides supported bilayers, membrane nanodiscs, and hybrid membranes, still an indisputably important tool for membrane b- physicists and biochemists. In vol. II of this book, the reader will fnd detailed methods for the use of liposomes in studying a variety of biochemical and biophysical membrane phenomena concomitant with chapters describing a great palette of state-of-the-art analytical technologies.


Contents:

1. Current Trends in Liposome Research
Tamer A. ElBayoumi and Vladimir P. Torchilin

2. Nanoliposomes: Preparation and Analysis
M. Reza Mozafari

3. Preparation of DRV Liposomes
Sophia G. Antimisiaris

4. Elastic Liposomes for Topical and Transdermal Drug Delivery
Heather A.E. Benson

5. Archaebacterial Tetraetherlipid Liposomes
Aybike Ozcetin, Samet Mutlu, and Udo Bakowsky

6. Cationic Magnetoliposomes
Marcel De Cuyper and Stefaan J.H. Soenen

7. Ultrasound-Responsive Liposomes
Shao-Ling Huang

8. Liposome Formulations of Hydrophobic Drugs
Reto A. Schwendener and Herbert Schott

9. Remote Loading of Anthracyclines into Liposomes
Felicitas Lewrick and Regine Peschka-Suss

10. Arsonoliposomes: Preparation and Physicochemical Characterization
Sophia G. Antimisiaris and Panayiotis V. Ioannou

11. Liposome-Based Vaccines
Reto A. Schwendener, Burkhard Ludewig, Andreas Cerny, and Olivier Engler

12. Mannosylated Liposomes for Targeted Vaccines Delivery
Suresh Prasad Vyas, Amit K. Goyal, and Kapil Khatri

13. Liposomes for Specific Depletion of Macrophages from Organs and Tissues
Nico van Rooijen and Esther Hendrikx

14. Vesicular Phospholipid Gels
Martin Brandl

15. Environment-Responsive Multifunctional Liposomes
Amit A. Kale and Vladimir P. Torchilin

16. Functional Liposomal Membranes for Triggered Release
Armagan Kocer

17. A 'Dock and Lock' Approach to Preparation of Targeted Liposomes
Marina V. Backer and Joseph M. Backer

18. Conjugation of Ligands to the Surface of Preformed Liposomes by Click Chemistry
Benoit Frisch, Fatouma Said Hassane, and Francis Schuber

19. Targeted MagneticLiposomes Loaded with Doxorubicin
Pallab Pradhan, Rinti Banerjee, Dhirendra Bahadur, Christian Koch, Olga Mykhaylyk, and Christian Plank

20. Liposomes for Drug Delivery to Mitochondria
Sarathi V. Boddapati, Gerard G.M. D'Souza, and Volkmar Weissig

21. Cytoskeletal-Antigen Specific Immunoliposomes: Preservation of Myocardial Viability
Vishwesh Patil, Tala Khudairi, and Ban-An Khaw

22. Gadolinium-Loaded Polychelating Polymer-Containing Tumor-Targeted Liposomes
Suna Erdogan and Vladimir P. Torchilin

23. Angiogenic Vessel-Targeting DDS by Liposomalized Oligopeptides
Tomohiro Asai and Naoto Oku

24. TAT-Peptide Modified Liposomes: Preparation, Characterization, and Cellular Interaction
Marjan M. Fretz and Gert Storm

25. ATP-Loaded Liposomes for Targeted Treatment in Models of Myocardial Ischemia
Tatyana S. Levchenko, William C. Hartner, Daya D. Verma, Eugene A. Bernstein, and Vladimir P. Torchilin

26. Intracellular ATP Delivery Using Highly Fusogenic Liposomes
Sufan Chien

27. Lipoplex Formation Using Liposomes Prepared by Ethanol Injection
Yoshie Maitani

28. Acid-Labile Liposome / pDNA Complexes
Michel Bessodes and Daniel Scherman

29. Serum-Resistant Lipoplexes in the Presence of Asialofetuin
Conchita Tros de ILarduya

30. Anionic pH Sensitive Lipoplexes
Nathalie Mignet and Daniel Scherman

31. Liposomal siRNA Delivery
Jeffrey Hughes, Preeti Yadava, and Ryan Mesaros

32. Complexation of siRNA and pDNA with Cationic Liposomes: The Important Aspects in Lipoplex Preparation
Jose Mario Barichello, Tatsuhiro Ishida, and Hiroshi Kiwada

33. Effective In Vitro and In Vivo Gene Delivery by The Combination of Liposomal Bubbles (Bubble Liposomes) and Ultrasound


PRODUCT DETAILS

ISBN-13: 9781603273596
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2009
Pages: 558
Weight: 1405g
Availability: Available
Subcategories: Pharmacology
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