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MORE ABOUT THIS BOOK
Main description:
Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls.
Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
Contents:
Immunotoxicity Testing: Methods and Protocols
Editor Rodney R. Dietert
Table of Contents:
Table of Contents
Preface
Contributors
Part I - Introduction
Immunotoxicology Testing: Past and Future
Michael I. Luster and G. Frank Gerberick
Part II - Overview and Health-Risk Considerations
Developmental Immunotoxicity (DIT): The Why, When and How of DIT Testing.
Rodney R. Dietert and Jamie DeWitt
An In Vivo Approach to Test Immunosensitization by Low Moelcular Weight Compounds
Irene S. Ludwig, Lydia M. Kwast, Danielle Fiechter, Raymond H.H. Pieters
Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing
Rodney R. Dietert, Janice M. Dietert and Jerrie Gavalchin
Markers of Inflammation
Dori R. Germolec, Rachel P. Frawley, and Ellen Evans
Evaluating Macrophages in Immunotoxicity Testing
John B. Barnett and Kathleen M. Brundage
Part III - Immunotoxicity and Host Resistance Models
Host Resistance Assays Including Bacterial Challenge
Florence G. Burleson and Gary R. Burleson
Viral Host Resistance Studies
Wendy Jo Freebern
Parasite Challenge as Host Resistance Models for Immunotoxicity Testing
Robert W. Luebke
Tumor Challenges in Immunotoxicity Testing
Sheung Ng, Kotaro Yoshida, and Judith T. Zelikoff
Part IV - Testing Protocols inRodents and Other Laboratory Animals
The T-dependent Antibody Response to Keyhole Limpet Hemocyanin in Rodents
Lisa M. Plitnick and Danuta J. Herzyk
The T-Dependent Antibody Response to Sheep Erythrocytes
Kimber L. White, Jr., Deborah L. Musgrove, and Ronnetta D. Brown
13. The Delayed Hypersensitivity (DTH) Assay Using Protein and Xenogeneic Cell Antigens
Rodney R. Dietert, Terry L. Bunn and Ji-Eun Lee
14. The Cytotoxic T Lymphocyte (CTL) Assay For Evaluating Cell-Mediated Immune Function
Gary R. Burleson, Florence G. Burleson and Rodney R. Dietert
15. NK Cell Assays in Immunotoxicity Testing
Qing Li
16. The Local Lymph Node Assay and Skin Sensitization Test
Ian Kimber and Rebecca J. Dearman
17. Use of Contact Hypersensitivity in Immunotoxicity Testing
Jacques Descotes
18. Evaluation of Apoptosis in Immunotoxicity Testing
Sadiye Amcaoglu Rieder, Dilip Vakharia, Prakash S. Nagarkatti
and Mitzi Nagarkatti
19. Dendritic Cells in Immunotoxicity Testing
Donghong Gao and David A. Lawrence
20. Evaluating Cytokines in Immunotoxicity Testing
Emanuela Corsini an
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: February, 2010
Pages: 442
Weight: 2160g
Availability: Available
Subcategories: General Issues, Pharmacology
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