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Target Discovery and Validation Reviews and Protocols

Emerging Molecular Targets and Treatment Options,Volume 2

Series: Methods in Molecular Biology

by Mouldy Sioud

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Target Discovery and Validation Reviews and Protocols

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Main description:

These volumes review the most current methods for drug target discovery and validation. They explore how recent improvement in understanding the molecular mechanisms of human pathology is impacting drug target discovery in the laboratory and in real therapeutics, specifically for cancers and autoimmune disorders. This book provides a thorough review of the most cutting-edge methods available for each step in drug target identification, validation, and clinical application.

Contents:

Part II: Emerging molecular targets and treatment options

1. Druggable signaling proteins
Mouldy Sioud and Marianne leirdal
2. DNA methylation and histone modifications in patients with cancer: Potential prognostic and therapeutic targets
Michael Herranz and Manel Esteller
3. Wnt signaling as therapeutic target for cancer
Andreas Herbst and Frank Thomas Kolligs
4. The NG2/HMP proteoglycan as a cancer therapeutic target
Martha Chekenya and Heike Immervoll
5. Heterotrimeric G proteins and disease
Oyvind Melien
6. High Mobility Group Box1 isoforms as potential therapeutic targets in sepsis
William Parrish and Luis Ulloa
7. Antisense oligonucleotides: Target validation and development of systemically-delivered therapeutic nanoparticles
Chuanbo Zhang, Jin Pei, Deepak Kumar, Isamu Sakabe, Howard E. Boudreau, Prafulla C. Gokhale, and Usha N. Kasid
8. Therapeutic applications of RNA-based aptamers
de Franciscis Vittorio
9. Guidelines for the selection of effective siRNA sequences for functional genomics and therapeutic applications
Kumiko Ui-Tei, Yuki Naito, and Kaoru Saigo
10. Suppression of apoptosis in the liver by systematic and local delivery of siRNA
Lars Zender and Stefan Kubicka
11. Inhibition of tumour growth by intratumoral delivery of siRNAs
Seyedhossein Aharinejad, Mouldy Sioud, Trevor Lucas, and Dietmar Abraham
12. Validation of telomerase and survivin as anticancer therapeutic targets using ribozymes and small interfering RNAs
Nadia Zaffaroni, Marzia Pennati, and Marco Folini
13. Collagen-induced arthritis in mice: A major role for TNFa
Richard O. Williams
14. Novel opportunities for therapeutic targeting in systemic autoimmune diseases
Meryem Ouarzane and Moncef Zouali
15. Regulatory RNAs: Future perspectives in diagnosis, prognosis and individualized therapy
ProvostPatrick
16. Therapeutic options and individualized medicine
Mouldy Sioud Oyvind Melien

NB. Chapters 8 and 15, which I am now editing, will be send on Monday.

PRODUCT DETAILS

ISBN-13: 9781617378270
Publisher: Springer (Humana Press Inc.)
Publication date: December, 2010
Pages: 356
Weight: 612g
Availability: Available
Subcategories: Oncology

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