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Cancer Stem Cells

Methods and Protocols

Series: Methods in Molecular Biology

by John S Yu

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Main description:

Cancer is a devastating disease that affects millions of people in the world. Our the- pies for tumors have mostly been based on classical chemotherapy and antiproliferative treatments. More recently, directed therapies against a causative oncogene have led to prominent reduction in tumor rates for some cancers. For instance, chronic myelogenous leukemia that is due to a BCR-ABL translocation can be targeted with Gleevec. Despite these advances in individual tumors, a number of patients are treated for their primary tumors and ultimately relapse. Relapsing tumors can be due to resistance to chemotherapy or to antioncogene drugs. Another hypothesis is that heterogeneity in the tumor leads to an inability of classical chemotherapy to completely eradicate all cells of the tumor. This concept of heterogeneity has led some investigators to propose a cancer stem cell model. As patients are treated with chemotherapy, most of the dividing cells are killed, but this leaves a small subset of cells that have the ability to remake the entire tumor. These are cancer stem cells. They possess the signals of self-renewal and yet can also differentiate. If one could understand more about the cells that remain after classical chemotherapy or the cells that can remake the tumor among the heterogeneous population, this information would have a huge impact on our treatment of cancer.

Contents:

1. Defining Cancer Stem Cells by Xenotransplantation in Zebrafish
Michael C. Dovey and Leonard I. Zon

2. Analysis of Cancer Stem Cell Metastasis in Xenograft Animal Models
Yibin Kang

3. Identification of Murine and Human Acute Myeloid Leukemia Stem Cells
Aniruddha J. Deshpande, Farid Ahmed, and Christian Buske

4. Methods for Analysis of Brain Tumor Stem Cell and Neural Stem Cell Self-Renewal
Ichiro Nakano and Harley I. Kornblum

5. Prospective Identification of Cancer Stem Cells with the Surface Antigen CD133
Kyeung Min Joo and Do-Hyun Nam

6. Neurosphere Culture and Human Organotypic Model to Evaluate Brain Tumor Stem Cells
Hugo Guerrero-Cazares, Kaisorn L. Chaichana, and Alfredo Quinones-Hinojosa

7. Methodologies in Assaying Prostate Cancer Stem Cells
Hangwen Li, Ming Jiang, Sofia Honorio, Lubna Patrawala, Collene R. Jeter, Tammy Calhoun-Davis, Simon W. Hayward, and Dean G. Tang

8. Characterization of Non-Malignant and Malignant Prostatic Stem/Progenitor Cells by Hoechst Side Population Method
Murielle Mimeault and Surinder K. Batra

9. Anchorage Independent Growth of Prostate Cancer Stem Cells
Shunyou Wang

10. Identification of Human Pancreatic Cancer Stem Cells
Chenwei Li, C.J. Lee, and Diane M. Simeone

11. Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma
Laurie Ailles and Mark Prince

12. Pituitary Adenoma Stem Cells
Patrizia Tunici and John S. Yu

13. Genome-Wide DNA Methylation Profiling: The mDIP-Chip Technology
Yin Shen, Shaun D. Fouse, and Guoping Fan

14. The Contribution of Niche-Derived Factors to the Regulation of Cancer Cells
Julie B. Sneddon

15. Dendritic Cell Vaccines for Cancer Stem Cells
Serena Pellegatta and GaetanoFinocchiaro

16. Maintaining and Engineering Neural Stem Cells for Delivery of Genetically Encoded Therapy to Brain Tumors
Jennifer Katz, Joseph Krueger, Brunhilde Felding-Habermann, and Evan Y. Snyder

17. Measurement of Multiple Drug Resistance Transporter Activity in Putative Cancer Stem/Progenitor Cells
Vera S. Donnenberg, E. Michael Meyer, and Albert D. Donnenberg

PRODUCT DETAILS

ISBN-13: 9781617797538
Publisher: Springer (Humana Press Inc.)
Publication date: August, 2012
Pages: 300
Weight: 637g
Availability: Available
Subcategories: Oncology

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