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Main description:
In Peptide Modifications to Increase Metabolic Stability and Activity, expert researchers in the field provide summarized methods for preparation, purification of modified peptides, and assessment of their biochemical activities. These methods and protocols include preparation of conformationally constrained peptides, modification of peptide bonds, introduction of nonproteinogenic amino acids, and alteration of peptides' physical and biological properties by modification of the amino acid side chains and/or terminal residues. With additional chapter that describes new experimental approach for the detection of exogenous peptides within living cells using peptides labeled with heavy isotopes and confocal Raman microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and practical, Peptide Modifications to Increase Metabolic Stability and Activity seeks to provide scientists with alternative approaches to peptide modification that many researchers may find applicable to their specific research requirements.
Contents:
1. Hantzsch Based Macrocyclization Approach for the Synthesis of Thiazole Containing Cyclopeptides
Adel Nefzi
2. The Chemical Synthesis of -Conotoxins and Structurally Modified Analogs with Enhanced Biological Stability
Jayati Banerjee, Reena Gyanda, Yi-Pin Chang, and Christopher J. Armishaw
3. Synthesis of AApeptides
Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai
4. Peptoids and Peptide - Peptoid Hybrid Biopolymers as Peptidomimetics
Maciej J. Stawikowski
5. Synthesis of Side Chain N,N'-diaminoalkylated Derivatives of Basic Amino Acids for Application in Solid-phase Peptide Synthesis
Jean-Philippe Pitteloud, Nina Bionda, and Predrag Cudic
6. Study Protein Folding and Aggregation Using Non-natural Amino Acid p-cyanophenylalanine as a Sensitive Optical Probe
Deguo Du, Haiyang Liu, and Bimlesh Ojha
7. AdamantoyLated Biologically Active Small Peptides and Glycopeptides Structurally Related to the Bacterial Peptidoglycan
Ruza Frkanec, Branka Vranesic, and Srdjanka Tomic
8. Optimization of Physicochemical and Pharmacological Properties of Peptide Drugs by Glycosylation
Maria C. Rodriguez and Mare Cudic
9. The Maillard Reaction Induced Modification of Endogenous Opioid Peptide Encephalin
Andreja Jakas
10. Solid-phase Guanidinylation of Peptidyl Amines Compatible with Standard Fmoc-chemistry: Formation of Monosubstituted Guanidines
Nina Bionda and Predrag Cudic
11. Stabilization of Collagen-Model, Triple-Helical Peptides for In Vitro and In Vivo Applications
Manishabrata Bhowmick and Gregg B. Fields
12. Identification of Adipokine Receptor Agonists and Turning Them to Antagonists
Laszlo Otvos, Jr.
13. Peptide Detection and Structure Determination in Live Cells using Confocal Raman Microscopy
Andrew C. Terentis and Jing Ye
PRODUCT DETAILS
Publisher: Springer (Humana Press Inc.)
Publication date: September, 2013
Pages: 250
Weight: 6221g
Availability: Available
Subcategories: Biochemistry
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