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Main description:
Regulation of gene expression, a major determinant of gene activity, occupies a central place in molecular biology. Yeast Genetic Networks: Methods and Protocols covers approaches to the systems biological analysis of small-scale gene networks in yeast. Divided into four convenient sections, this detailed volume discusses the methods used to analyze gene expression quantitatively, presents a collection of mathematical and computational tools to analyze stochasticity, adaptation, sensitivity in signal transmission, and oscillations in gene expression, provides instructional methods on how to utilize the tools of quantitative genetics to identify genes that regulate stochasticity and oscillations in gene expression, and concludes with a section devoted to the analysis of conserved gene expression systems and networks in different fungal species. Written in the highly successful Methods in Molecular Biologyâ„¢ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
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Authoritative and accessible, Yeast Genetic Networks: Methods and Protocols serves as an ideal and valuable resource for both novices and experienced researchers.
Feature:
Includes cutting-edge methods and protocols
Provides step-by-step detail essential for reproducible results
Contains key notes and implementation advice from the experts
Back cover:
Regulation of gene expression, a major determinant of gene activity, occupies a central place in molecular biology. Yeast Genetic Networks: Methods and Protocols covers approaches to the systems biological analysis of small-scale gene networks in yeast. Divided into four convenient sections, this detailed volume discusses the methods used to analyze gene expression quantitatively, presents a collection of mathematical and computational tools to analyze stochasticity, adaptation, sensitivity in signal transmission, and oscillations in gene expression, provides instructional methods on how to utilize the tools of quantitative genetics to identify genes that regulate stochasticity and oscillations in gene expression, and concludes with a section devoted to the analysis of conserved gene expression systems and networks in different fungal species. Written in the highly successful Methods in Molecular Biologyâ„¢ series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
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Authoritative and accessible, Yeast Genetic Networks: Methods and Protocols serves as an ideal and valuable resource for both novices and experienced researchers.
Contents:
Part I Experimental Analysis of Signalling in Gene Regulatory Networks
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1. Global Estimation of mRNA Stability in Yeast
           Julia MarÃn-Navarro, Alexandra Jauhiainen, JoaquÃn Moreno, Paula Alepuz, José E. Pérez-OrtÃn, and Per Sunnerhagen
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2. Genomic-wide Methods to Evaluate Transcription Rates in Yeast
           José GarcÃa-MartÃnez, Vicent Pelechano, and José E. Pérez-OrtÃn
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3. Construction of Cis-regulatory Input Functions of Yeast Promoters
           Prasuna Ratna and Attila Becskei
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4. Luminescence as a Continuous Real-Time Reporter of Promoter Activity in Yeast Undergoing Respiratory Oscillations or Cell Division Rhythms
           J. Brian Robertson and Carl Hirschie Johnson
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5. Linearizer Gene Circuits with Negative Feedback Regulation
           Dmitry Nevozhay, Rhys M. Adams, and Gábor Balázsi
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6. Measuring In vivo Signaling Kinetics in a Mitogen-activated Kinase Pathway using Dynamic Input Stimulation
           Megan N. McClean, Pascal Hersen, and Sharad Ramanathan
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Part II Mathematical Modelling of Network Behavior
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7. Stochastic Analysis of Gene Expression
           Xiu-Deng Zheng and Yi Tao
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8. Studying Adaptation and Homeostatic Behaviors of Kinetic Networks by using MATLAB
           Tormod Drengstig, Thomas Kjosmoen, and Peter Ruoff
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9. Biochemical Systems Analysis of Signaling Pathways to Understand Fungal Pathogenicity
           Jacqueline Garcia, Kellie J. Sims, John H. Schwacke, and Maurizio Del Poeta
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10. Clustering Change Patterns Using Fourier Transformation with Time-course Gene Expression Data
           Jaehee Kim
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Part III Analysis of Network Behaviour by Quantitative Genetics
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11. Finding Modulators of Stochasticity Levels by Quantitative Genetics
           Steffen Fehrmann and Gaël Yvert
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12. Functional Mapping of Expression Quantitative Trait Loci That Regulate Oscillatory Gene Expression
           Arthur Berg, Ning Li, Chunfa Tong, Zhong Wang, Scott A. Berceli, and Rongling Wu
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Part IV Examination of Network Behaviour in Related Yeast Species
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13. Evolutionary Aspects of a Genetic Network: Studying the Lactose/Galactose Regulon of Kluyveromyces lactis
           Alexander Anders and Karin D. Breunig
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14. Analysis of Subtelomeric Silencing in Candida glabrata
           Alejandro Juárez-Reyes, Alejandro De Las Peñas, and Irene Castaño
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15. Morphological and Molecular Genetic Analysis of Epigenetic Switching of the Human Fungal Pathogen Candida albicans
           Denes Hnisz, Michael Tscherner, and Karl Kuchler
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16. Quantitation of Cellular Components in Cryptococcus neoformans for System Biology Analysis
           Arpita Singh, Asfia Qureshi, and Maurizio Del Poeta
PRODUCT DETAILS
Publisher: Springer (Humana Press)
Publication date: April, 2011
Pages: 305
Weight: 862g
Availability: Not available (reason unspecified)
Subcategories: Genetics
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